caa a22 4500 60550458X CHVBK 20210128100617.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00253-015-6941-2 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6941-2 Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research [Elektronische Daten] [Ouafae Akkouh, Tzi Ng, Randy Cheung, Jack Wong, Wenliang Pan, Charlene Ng, Ou Sha, Pang Shaw, Wai Chan] Ribosome-inactivating proteins (RIPs) are enzymes which depurinate ribosomal RNA (rRNA), thus impeding the process of translation resulting in inhibition of protein synthesis. They are produced by various organisms including plants, fungi and bacteria. RIPs from plants are linked to plant defense due to their antiviral, antifungal, antibacterial, and insecticidal activities in which they can be applied in agriculture to combat microbial pathogens and pests. Their anticancer, antiviral, embryotoxic, and abortifacient properties may find medicinal applications. Besides, conjugation of RIPs with antibodies or other carriers to form immunotoxins has been found useful to research in neuroscience and anticancer therapy. Springer-Verlag Berlin Heidelberg, 2015 Ribosome-inactivating proteins nationallicence Antiviral nationallicence Antifungal nationallicence Insecticidal nationallicence Anticancer nationallicence Akkouh Ouafae Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK, Leiden, The Netherlands aut Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Pan Wenliang School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Ng Charlene School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Sha Ou School of Medicine, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen, China aut Shaw Pang School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Chan Wai School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/23(2015-12-01), 9847-9863 0175-7598 99:23<9847 2015 99 253 https://doi.org/10.1007/s00253-015-6941-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6941-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akkouh Ouafae Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Pan Wenliang School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Ng Charlene School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Sha Ou School of Medicine, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen, China aut NATIONALLICENCE 700 1- Shaw Pang School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 700 1- Chan Wai School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/23(2015-12-01), 9847-9863 0175-7598 99:23<9847 2015 99 253