Overview on the biotechnological production of l -DOPA
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| 024 | 7 | 0 | |a 10.1007/s00253-014-6215-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-014-6215-4 | ||
| 245 | 0 | 0 | |a Overview on the biotechnological production of l -DOPA |h [Elektronische Daten] |c [Kyoungseon Min, Kyungmoon Park, Don-Hee Park, Young Yoo] |
| 520 | 3 | |a l-DOPA (3,4-dihydroxyphenyl-l-alanine) has been widely used as a drug for Parkinson's disease caused by deficiency of the neurotransmitter dopamine. Since Monsanto developed the commercial process for l-DOPA synthesis for the first time, most of currently supplied l-DOPA has been produced by the asymmetric method, especially asymmetric hydrogenation. However, the asymmetric synthesis shows critical limitations such as a poor conversion rate and a low enantioselectivity. Accordingly, alternative biotechnological approaches have been researched for overcoming the shortcomings: microbial fermentation using microorganisms with tyrosinase, tyrosine phenol-lyase, or p-hydroxyphenylacetate 3-hydroxylase activity and enzymatic conversion by immobilized tyrosinase. Actually, Ajinomoto Co. Ltd commercialized Erwinia herbicola fermentation to produce l-DOPA from catechol. In addition, the electroenzymatic conversion system was recently introduced as a newly emerging scheme. In this review, we aim to not only overview the biotechnological l-DOPA production methods, but also to briefly compare and analyze their advantages and drawbacks. Furthermore, we suggest the future potential of biotechnological l-DOPA production as an industrial process. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a l -DOPA |2 nationallicence | |
| 690 | 7 | |a Microbial fermentation |2 nationallicence | |
| 690 | 7 | |a Immobilized tyrosinase |2 nationallicence | |
| 690 | 7 | |a Electroenzymatic system |2 nationallicence | |
| 700 | 1 | |a Min |D Kyoungseon |u Clean Energy Research Center, Korea Institute of Science and Technology, 136-791, Seoul, South Korea |4 aut | |
| 700 | 1 | |a Park |D Kyungmoon |u Department of Biological and Chemical Engineering, Hongik University, 339-701, Sejong, South Korea |4 aut | |
| 700 | 1 | |a Park |D Don-Hee |u Department of Biotechnology and Bioengineering, Chonnam National University, 500-751, Gwangju, South Korea |4 aut | |
| 700 | 1 | |a Yoo |D Young |u School of Chemical and Biological Engineering, Seoul National University, 151-742, Seoul, South Korea |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/2(2015-01-01), 575-584 |x 0175-7598 |q 99:2<575 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-014-6215-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-014-6215-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Min |D Kyoungseon |u Clean Energy Research Center, Korea Institute of Science and Technology, 136-791, Seoul, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Park |D Kyungmoon |u Department of Biological and Chemical Engineering, Hongik University, 339-701, Sejong, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Park |D Don-Hee |u Department of Biotechnology and Bioengineering, Chonnam National University, 500-751, Gwangju, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yoo |D Young |u School of Chemical and Biological Engineering, Seoul National University, 151-742, Seoul, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/2(2015-01-01), 575-584 |x 0175-7598 |q 99:2<575 |1 2015 |2 99 |o 253 | ||