Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6926-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6926-1 | ||
| 245 | 0 | 0 | |a Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens |h [Elektronische Daten] |c [Mohammad Rahnamaeian, Andreas Vilcinskas] |
| 520 | 3 | |a Antimicrobial peptides (AMPs) are components of the innate immune system in many species of animals. Their diverse spectrum of activity against microbial pathogens, both as innate defense molecules and immunomodulators, makes them attractive candidates for the development of a new generation of antibiotics. Although the potential immunogenicity of AMPs means they are not suitable for injection and their susceptibility to digestive peptidases is likely to reduce their oral efficacy, they are ideal for topical formulations such as lotions, creams, shampoos, and wound dressings and could therefore be valuable products for the cosmetic industry. In this context, short AMPs (<20 amino acids) lacking disulfide bonds combine optimal antimicrobial activity with inexpensive chemical synthesis and are therefore more compatible with large-scale production and the modifications required to ensure stability, low toxicity, and microbial specificity. Proof-of-concept for the application of AMPs as novel anti-infectives has already been provided in clinical trials. This perspective considers the anti-infective properties of short AMPs lacking disulfide bonds, which are active against dermatologically important microflora. We consider the challenges that need to be addressed to facilitate the prophylactic application of AMPs in personal care products. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a Anti-infective |2 nationallicence | |
| 690 | 7 | |a Antimicrobial peptides |2 nationallicence | |
| 690 | 7 | |a Cosmetic industry |2 nationallicence | |
| 690 | 7 | |a Dermal pathogens |2 nationallicence | |
| 690 | 7 | |a Prophylaxis |2 nationallicence | |
| 690 | 7 | |a Skin diseases |2 nationallicence | |
| 700 | 1 | |a Rahnamaeian |D Mohammad |u Fraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Winchester Strasse 2, 35394, Giessen, Germany |4 aut | |
| 700 | 1 | |a Vilcinskas |D Andreas |u Fraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Winchester Strasse 2, 35394, Giessen, Germany |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/21(2015-11-01), 8847-8855 |x 0175-7598 |q 99:21<8847 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6926-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6926-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rahnamaeian |D Mohammad |u Fraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Winchester Strasse 2, 35394, Giessen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vilcinskas |D Andreas |u Fraunhofer Institute for Molecular Biology and Applied Ecology, Department of Bioresources, Winchester Strasse 2, 35394, Giessen, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/21(2015-11-01), 8847-8855 |x 0175-7598 |q 99:21<8847 |1 2015 |2 99 |o 253 | ||