Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus
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| 008 | 210128e20151101xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00253-015-6786-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6786-8 | ||
| 245 | 0 | 0 | |a Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus |h [Elektronische Daten] |c [Yang Xu, Tingting Zhang, Qianqian Xu, Zongxi Han, Shuling Liang, Yuhao Shao, Deying Ma, Shengwang Liu] |
| 520 | 3 | |a The host innate immune response either clears invading viruses or allows the adaptive immune system to establish an effective antiviral response. In this study, both pathogenic (passage 3, P3) and attenuated (P110) infectious bronchitis virus (IBV) strains were used to study the immune responses of chicken to IBV infection. Expression of avian β-defensins (AvBDs) and Toll-like receptors (TLRs) in 16 tissues of chicken were compared at 7days PI. The results showed that P3 infection upregulated the expression of AvBDs, including AvBD2, 4, 5, 6, 9, and 12, while P110 infection downregulated the expression of AvBDs, including AvBD3, 4, 5, 6, and 9 in most tissues. Meanwhile, the expression level of several TLRs showed a general trend of upregulation in the tissues of P3-infected chickens, while they were downregulated in the tissues of P110-infected chickens. The result suggested that compared with the P110 strain, the P3 strain induced a more pronounced host innate immune response. Furthermore, we observed that recombinant AvBDs (including 2, 6, and 12) demonstrated obvious anti-viral activity against IBV in vitro. Our findings contribute to the proposal that IBV infection induces an increase in the messenger RNA (mRNA) expression of some AvBDs and TLRs, which suggests that AvBDs may play significant roles in the resistance of chickens to IBV replication. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Chicken |2 nationallicence | |
| 690 | 7 | |a Avian β-defensins |2 nationallicence | |
| 690 | 7 | |a Toll-like receptors |2 nationallicence | |
| 690 | 7 | |a Infectious bronchitis virus |2 nationallicence | |
| 700 | 1 | |a Xu |D Yang |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Zhang |D Tingting |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Xu |D Qianqian |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Han |D Zongxi |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Liang |D Shuling |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Shao |D Yuhao |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Ma |D Deying |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | |
| 700 | 1 | |a Liu |D Shengwang |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/21(2015-11-01), 9011-9024 |x 0175-7598 |q 99:21<9011 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6786-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6786-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Yang |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhang |D Tingting |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Qianqian |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Han |D Zongxi |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liang |D Shuling |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shao |D Yuhao |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ma |D Deying |u College of Animal Science and Technology, Northeast Agricultural University, 150030, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Shengwang |u Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150001, Harbin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/21(2015-11-01), 9011-9024 |x 0175-7598 |q 99:21<9011 |1 2015 |2 99 |o 253 | ||