caa a22 4500 605506361 CHVBK 20210128100626.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00253-015-6637-7 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6637-7 Biomarkers for infection: enzymes, microbes, and metabolites [Elektronische Daten] [Gregor Tegl, Doris Schiffer, Eva Sigl, Andrea Heinzle, Georg Guebitz] Wound infection is a severe complication causing delayed healing and risks for patients. Conventional methods of diagnosis for infection involve error-prone clinical description of the wound and time-consuming microbiological tests. More reliable alternatives are still rare, except for invasive and unaffordable gold standard methods. This review discusses the diversity of new approaches for wound infection determination. There has been progress in the detection methods of microorganisms, including the assessment of the diversity of the bacterial community present in a wound, as well as in the elaboration of specific markers. Another interesting strategy involves the quantification of enzyme activities in the wound fluid secreted by the immune system as response to infection. Color-changing substrates for these enzymes consequently have been shown to allow detection of an infection in wounds in a fast and easy way. Promising results were also delivered in measuring pH changes or detecting enhanced amounts of volatile molecules in case of infection. A simple and effective infection detection tool is not yet on the market, but innovative ideas pave the way for the investigation of fast and easy point-of-care devices. Springer-Verlag Berlin Heidelberg, 2015 Infection detection nationallicence Chronic wounds nationallicence Sensors nationallicence Diagnostic nationallicence Point of care nationallicence Tegl Gregor Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut Schiffer Doris Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut Sigl Eva Qualizyme GmbH, Neue Stiftingtalstrasse 2, 8010, Graz, Austria aut Heinzle Andrea Austrian Centre of Industrial Biotechnology, Petersgasse 14, 8010, Graz, Austria aut Guebitz Georg Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/11(2015-06-01), 4595-4614 0175-7598 99:11<4595 2015 99 253 https://doi.org/10.1007/s00253-015-6637-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6637-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tegl Gregor Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut NATIONALLICENCE 700 1- Schiffer Doris Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut NATIONALLICENCE 700 1- Sigl Eva Qualizyme GmbH, Neue Stiftingtalstrasse 2, 8010, Graz, Austria aut NATIONALLICENCE 700 1- Heinzle Andrea Austrian Centre of Industrial Biotechnology, Petersgasse 14, 8010, Graz, Austria aut NATIONALLICENCE 700 1- Guebitz Georg Department of Environmental Biotechnology, University of Natural Resources and Life Sciences Vienna, Konrad Lorenz Strasse 20, 3430, Tulln an der Donau, Austria aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/11(2015-06-01), 4595-4614 0175-7598 99:11<4595 2015 99 253