caa a22 4500 605506426 CHVBK 20210128100627.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00253-015-6622-1 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6622-1 Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications [Elektronische Daten] [Richa Singh, Utkarsha Shedbalkar, Sweety Wadhwani, Balu Chopade] Silver nanoparticles (AgNPs) have received tremendous attention due to their significant antimicrobial properties. Large numbers of reports are available on the physical, chemical, and biological syntheses of colloidal AgNPs. Since there is a great need to develop ecofriendly and sustainable methods, biological systems like bacteria, fungi, and plants are being employed to synthesize these nanoparticles. The present review focuses specifically on bacteria-mediated synthesis of AgNPs, its mechanism, and applications. Bacterial synthesis of extra- and intracellular AgNPs has been reported using biomass, supernatant, cell-free extract, and derived components. The extracellular mode of synthesis is preferred over the intracellular mode owing to easy recovery of nanoparticles. Silver-resistant genes, c-type cytochromes, peptides, cellular enzymes like nitrate reductase, and reducing cofactors play significant roles in AgNP synthesis in bacteria. Organic materials released by bacteria act as natural capping and stabilizing agents for AgNPs, thereby preventing their aggregation and providing stability for a longer time. Regulation over reaction conditions has been suggested to control the morphology, dispersion, and yield of nanoparticles. Bacterial AgNPs have anticancer and antioxidant properties. Moreover, the antimicrobial activity of AgNPs in combination with antibiotics signifies their importance in combating the multidrug-resistant pathogenic microorganisms. Multiple microbicidal mechanisms exhibited by AgNPs, depending upon their size and shape, make them very promising as novel nanoantibiotics. Springer-Verlag Berlin Heidelberg, 2015 Silver nanoparticles (AgNPs) nationallicence Bacteria nationallicence Synthesis nationallicence Antimicrobial nationallicence Mechanism nationallicence Applications nationallicence Singh Richa Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut Shedbalkar Utkarsha Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut Wadhwani Sweety Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut Chopade Balu Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/11(2015-06-01), 4579-4593 0175-7598 99:11<4579 2015 99 253 https://doi.org/10.1007/s00253-015-6622-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6622-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Singh Richa Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut NATIONALLICENCE 700 1- Shedbalkar Utkarsha Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut NATIONALLICENCE 700 1- Wadhwani Sweety Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut NATIONALLICENCE 700 1- Chopade Balu Department of Microbiology, Savitribai Phule Pune University, 411007, Pune, India aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/11(2015-06-01), 4579-4593 0175-7598 99:11<4579 2015 99 253