Pseudomonas putida —a versatile host for the production of natural products
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6745-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6745-4 | ||
| 245 | 0 | 0 | |a Pseudomonas putida —a versatile host for the production of natural products |h [Elektronische Daten] |c [Anita Loeschcke, Stephan Thies] |
| 520 | 3 | |a The biosynthesis of natural products by heterologous expression of biosynthetic pathways in amenable production strains enables biotechnological access to a variety of valuable compounds by conversion of renewable resources. Pseudomonas putida has emerged as a microbial laboratory work horse, with elaborated techniques for cultivation and genetic manipulation available. Beyond that, this bacterium offers several particular advantages with regard to natural product biosynthesis, notably a versatile intrinsic metabolism with diverse enzymatic capacities as well as an outstanding tolerance to xenobiotics. Therefore, it has been applied for recombinant biosynthesis of several valuable natural products. This review provides an overview of applications of P. putida as a host organism for the recombinant biosynthesis of such natural products, including rhamnolipids, terpenoids, polyketides and non-ribosomal peptides, and other amino acid-derived compounds. The focus is on de novo natural product synthesis from intrinsic building blocks by means of heterologous gene expression and strain engineering. Finally, the future potential of the bacterium as a chassis organism for synthetic microbiology is pointed out. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a Pseudomonas putida |2 nationallicence | |
| 690 | 7 | |a Heterologous pathway expression |2 nationallicence | |
| 690 | 7 | |a Recombinant biosynthesis |2 nationallicence | |
| 690 | 7 | |a Natural products |2 nationallicence | |
| 700 | 1 | |a Loeschcke |D Anita |u Institut für Molekulare Enzymtechnologie, Heinrich-Heine-Universität Düsseldorf, Forschungszentrum Jülich, 52426, Jülich, Germany |4 aut | |
| 700 | 1 | |a Thies |D Stephan |u Institut für Molekulare Enzymtechnologie, Heinrich-Heine-Universität Düsseldorf, Forschungszentrum Jülich, 52426, Jülich, Germany |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/15(2015-08-01), 6197-6214 |x 0175-7598 |q 99:15<6197 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6745-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6745-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Loeschcke |D Anita |u Institut für Molekulare Enzymtechnologie, Heinrich-Heine-Universität Düsseldorf, Forschungszentrum Jülich, 52426, Jülich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Thies |D Stephan |u Institut für Molekulare Enzymtechnologie, Heinrich-Heine-Universität Düsseldorf, Forschungszentrum Jülich, 52426, Jülich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/15(2015-08-01), 6197-6214 |x 0175-7598 |q 99:15<6197 |1 2015 |2 99 |o 253 | ||