caa a22 4500 605506833 CHVBK 20210128100629.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00775-014-1208-4 doi (NATIONALLICENCE)springer-10.1007/s00775-014-1208-4 Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer [Elektronische Daten] [Lydia Paul, Bruno Therrien, Julien Furrer] The reactivity of three hexacationic arene ruthenium metallaprisms towards isolated nucleotides and a short DNA strand was investigated using NMR spectroscopy, ESI mass spectrometry, UV/Vis and circular dichroism spectroscopy. The metallaprism built from oxalato-bridging ligands reacts rapidly in the presence of deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate, while the benzoquinonato derivative only reacts with dGMP. On the other hand, the larger metallaprism incorporating naphtoquinonato bridges remains stable in the presence of nucleotides. The reactivity of the three hexacationic metallaprisms with the decameric oligonucleotide d(CGCGATCGCG)2 was also investigated. Analysis of the NMR, MS, UV/Vis and CD data suggests that no adducts are formed between the oligonucleotide and the metallaprisms, but electrostatic interactions, leading to partial unwinding of the double-stranded oligonucleotide, were evidenced. SBIC, 2014 Ruthenium nationallicence Metallaprisms nationallicence Nucleotides nationallicence DNA interaction nationallicence AA : Amino acid nationallicence dhbq : 2,5-Dihydroxy-1,4-benzoquinonato nationallicence dhnq : 5,8-Dihydroxy-1,4-naphthoquinonato nationallicence DOSY : Diffusion-ordered spectroscopy nationallicence ESI : Electrospray ionization nationallicence oxa : Oxalato nationallicence tpt : 2,4,6-Tri(pyridin-4-yl)-1,3,5-triazine nationallicence Paul Lydia Departement für Chemie und Biochemie, Universität Bern, 3012, Bern, Switzerland aut Therrien Bruno Institut de Chimie, Université de Neuchâtel, 2000, Neuchâtel, Switzerland aut Furrer Julien Departement für Chemie und Biochemie, Universität Bern, 3012, Bern, Switzerland aut JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/1(2015-01-01), 49-59 0949-8257 20:1<49 2015 20 775 https://doi.org/10.1007/s00775-014-1208-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00775-014-1208-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paul Lydia Departement für Chemie und Biochemie, Universität Bern, 3012, Bern, Switzerland aut NATIONALLICENCE 700 1- Therrien Bruno Institut de Chimie, Université de Neuchâtel, 2000, Neuchâtel, Switzerland aut NATIONALLICENCE 700 1- Furrer Julien Departement für Chemie und Biochemie, Universität Bern, 3012, Bern, Switzerland aut NATIONALLICENCE 773 0- JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/1(2015-01-01), 49-59 0949-8257 20:1<49 2015 20 775