Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1283-1 |2 doi |
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| 245 | 0 | 0 | |a Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents |h [Elektronische Daten] |c [Benoît Bertrand, Anna Citta, Inge Franken, Michel Picquet, Alessandra Folda, Valeria Scalcon, Maria Rigobello, Pierre Le Gendre, Angela Casini, Ewen Bodio] |
| 520 | 3 | |a While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or industrial syntheses, their potential to form transition metal complexes for medicinal applications has still to be exploited. Within this frame, we synthesized new homo- and heterobimetallic complexes based on the Au(I)-NHC scaffold. The compounds were synthesized via a microwave-assisted method developed in our laboratories using Au(I)-NHC complexes carrying a pentafluorophenol ester moiety and another Au(I) phosphane complex or a bipyridine ligand bearing a pendant amine function. Thus, we developed two different methods to prepare homo- and heterobimetallic complexes (Au(I)/Au(I) or Au(I)/Cu(II), Au(I)/Ru(II), respectively). All the compounds were fully characterized by several spectroscopic techniques including far infrared, and were tested for their antiproliferative effects in a series of human cancer cells. They showed moderate anticancer properties. Their toxic effects were also studied ex vivo using the precision-cut tissue slices (PCTS) technique and initial results concerning their reactivity with the seleno-enzyme thioredoxin reductase were obtained. | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a N -heterocyclic carbene |2 nationallicence | |
| 690 | 7 | |a Bimetallic complex |2 nationallicence | |
| 690 | 7 | |a Gold complex |2 nationallicence | |
| 690 | 7 | |a Anticancer drug |2 nationallicence | |
| 690 | 7 | |a Thioredoxin reductase |2 nationallicence | |
| 700 | 1 | |a Bertrand |D Benoît |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | |
| 700 | 1 | |a Citta |D Anna |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | |
| 700 | 1 | |a Franken |D Inge |u Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands |4 aut | |
| 700 | 1 | |a Picquet |D Michel |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | |
| 700 | 1 | |a Folda |D Alessandra |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | |
| 700 | 1 | |a Scalcon |D Valeria |u Institute of Neuroscience, C.N.R., viale G. Colombo 3, Padua, Italy |4 aut | |
| 700 | 1 | |a Rigobello |D Maria |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | |
| 700 | 1 | |a Le Gendre |D Pierre |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | |
| 700 | 1 | |a Casini |D Angela |u Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands |4 aut | |
| 700 | 1 | |a Bodio |D Ewen |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/6(2015-09-01), 1005-1020 |x 0949-8257 |q 20:6<1005 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1283-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1283-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bertrand |D Benoît |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Citta |D Anna |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Franken |D Inge |u Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Picquet |D Michel |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Folda |D Alessandra |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Scalcon |D Valeria |u Institute of Neuroscience, C.N.R., viale G. Colombo 3, Padua, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rigobello |D Maria |u Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Le Gendre |D Pierre |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Casini |D Angela |u Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bodio |D Ewen |u Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/6(2015-09-01), 1005-1020 |x 0949-8257 |q 20:6<1005 |1 2015 |2 20 |o 775 | ||