caa a22 4500 605507090 CHVBK 20210128100630.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00775-015-1283-1 doi (NATIONALLICENCE)springer-10.1007/s00775-015-1283-1 Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents [Elektronische Daten] [Benoît Bertrand, Anna Citta, Inge Franken, Michel Picquet, Alessandra Folda, Valeria Scalcon, Maria Rigobello, Pierre Le Gendre, Angela Casini, Ewen Bodio] While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or industrial syntheses, their potential to form transition metal complexes for medicinal applications has still to be exploited. Within this frame, we synthesized new homo- and heterobimetallic complexes based on the Au(I)-NHC scaffold. The compounds were synthesized via a microwave-assisted method developed in our laboratories using Au(I)-NHC complexes carrying a pentafluorophenol ester moiety and another Au(I) phosphane complex or a bipyridine ligand bearing a pendant amine function. Thus, we developed two different methods to prepare homo- and heterobimetallic complexes (Au(I)/Au(I) or Au(I)/Cu(II), Au(I)/Ru(II), respectively). All the compounds were fully characterized by several spectroscopic techniques including far infrared, and were tested for their antiproliferative effects in a series of human cancer cells. They showed moderate anticancer properties. Their toxic effects were also studied ex vivo using the precision-cut tissue slices (PCTS) technique and initial results concerning their reactivity with the seleno-enzyme thioredoxin reductase were obtained. SBIC, 2015 N -heterocyclic carbene nationallicence Bimetallic complex nationallicence Gold complex nationallicence Anticancer drug nationallicence Thioredoxin reductase nationallicence Bertrand Benoît Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut Citta Anna Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut Franken Inge Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Picquet Michel Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut Folda Alessandra Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut Scalcon Valeria Institute of Neuroscience, C.N.R., viale G. Colombo 3, Padua, Italy aut Rigobello Maria Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut Le Gendre Pierre Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut Casini Angela Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Bodio Ewen Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/6(2015-09-01), 1005-1020 0949-8257 20:6<1005 2015 20 775 https://doi.org/10.1007/s00775-015-1283-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00775-015-1283-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertrand Benoît Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut NATIONALLICENCE 700 1- Citta Anna Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut NATIONALLICENCE 700 1- Franken Inge Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Picquet Michel Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut NATIONALLICENCE 700 1- Folda Alessandra Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut NATIONALLICENCE 700 1- Scalcon Valeria Institute of Neuroscience, C.N.R., viale G. Colombo 3, Padua, Italy aut NATIONALLICENCE 700 1- Rigobello Maria Department of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, Padua, Italy aut NATIONALLICENCE 700 1- Le Gendre Pierre Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut NATIONALLICENCE 700 1- Casini Angela Department of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Bodio Ewen Institut de Chimie Moléculaire, UMR 6302 CNRS Université de Bourgogne Franche Comté, 9 Avenue A. Savary, 21078, Dijon, France aut NATIONALLICENCE 773 0- JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/6(2015-09-01), 1005-1020 0949-8257 20:6<1005 2015 20 775