Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00775-015-1290-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1290-2 | ||
| 245 | 0 | 0 | |a Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs |h [Elektronische Daten] |c [Justin Jagodinsky, Agnieszka Sulima, Yiqi Cao, Joanna Poprawski, Burchelle Blackman, John Lloyd, Rolf Swenson, Michael Gottesman, Matthew Hall] |
| 520 | 3 | |a The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence have been extensively studied in the laboratory setting, sometimes by generating fluorophore-tagged analogs. Here, we synthesized two Pt(II) complexes containing ethane-1,2-diamine ligands linked to a BODIPY fluorophore, and compared their biological activity with previously reported Pt(II) complexes conjugated to carboxyfluorescein and carboxyfluorescein diacetate. The cytotoxicity and DNA damage capacity of Pt-fluorophore complexes was compared to cisplatin, and the Pt-BODIPY complexes were found to be more cytotoxic with reduced cytotoxicity in cisplatin-resistant cells. Microscopy revealed a predominately cytosolic localization, with nuclear distribution at higher concentrations. Spheroids grown from parent and resistant cells revealed penetration of Pt-BODIPY into spheroids, and retention of the cisplatin-resistant spheroid phenotype. While most activity profiles were retained for the Pt-BODIPY complexes, accumulation in resistant cells was only slightly affected, suggesting that some aspects of Pt-fluorophore cellular pharmacology deviate from cisplatin. | |
| 540 | |a SBIC (outside the USA), 2015 | ||
| 690 | 7 | |a Accumulation |2 nationallicence | |
| 690 | 7 | |a Trafficking |2 nationallicence | |
| 690 | 7 | |a Platinum |2 nationallicence | |
| 690 | 7 | |a Resistance |2 nationallicence | |
| 700 | 1 | |a Jagodinsky |D Justin |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Sulima |D Agnieszka |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | |
| 700 | 1 | |a Cao |D Yiqi |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Poprawski |D Joanna |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Blackman |D Burchelle |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | |
| 700 | 1 | |a Lloyd |D John |u Advanced Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Swenson |D Rolf |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | |
| 700 | 1 | |a Gottesman |D Michael |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | |
| 700 | 1 | |a Hall |D Matthew |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/7(2015-10-01), 1081-1095 |x 0949-8257 |q 20:7<1081 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1290-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1290-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jagodinsky |D Justin |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sulima |D Agnieszka |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cao |D Yiqi |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Poprawski |D Joanna |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Blackman |D Burchelle |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lloyd |D John |u Advanced Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Swenson |D Rolf |u Imaging Probe Development Center, National Institutes of Health, Rockville, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gottesman |D Michael |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hall |D Matthew |u Laboratory of Cell Biology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Rm. 2108, 20892, Bethesda, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/7(2015-10-01), 1081-1095 |x 0949-8257 |q 20:7<1081 |1 2015 |2 20 |o 775 | ||