High-resolution crystal structure of Z-DNA in complex with Cr3+ cations
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1247-5 |2 doi |
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| 245 | 0 | 0 | |a High-resolution crystal structure of Z-DNA in complex with Cr3+ cations |h [Elektronische Daten] |c [Pawel Drozdzal, Miroslaw Gilski, Ryszard Kierzek, Lechoslaw Lomozik, Mariusz Jaskolski] |
| 520 | 3 | |a This work is part of our project aimed at characterizing metal-binding properties of left-handed Z-DNA helices. The three Cr3+ cations found in the asymmetric unit of the d(CGCGCG)2-Cr3+ crystal structure do not form direct coordination bonds with atoms of the Z-DNA molecule. Instead, the hydrated Cr3+ ions are engaged in outer-sphere interactions with phosphate groups and O6 and N7 guanine atoms of the DNA. The Cr3+(1) and Cr3+(2) ions have disordered coordination spheres occupied by six water molecules each. These partial-occupancy chromium cations are 2.354(15)Å apart and are bridged by three water molecules from their hydration spheres. The Cr3+(3) cation has distorted square pyramidal geometry. In addition to the high degree of disorder of the DNA backbone, alternate conformations are also observed for the deoxyribose and base moieties of the G2 nucleotide. Our work illuminates the question of conformational flexibility of Z-DNA and its interaction mode with transition-metal cations. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a Z-DNA |2 nationallicence | |
| 690 | 7 | |a Chromium |2 nationallicence | |
| 690 | 7 | |a X-ray crystallography |2 nationallicence | |
| 690 | 7 | |a Spm : Spermine |2 nationallicence | |
| 690 | 7 | |a Spk : Sperminium tetracation |2 nationallicence | |
| 690 | 7 | |a Put2+ : Putrescinium dication |2 nationallicence | |
| 700 | 1 | |a Drozdzal |D Pawel |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | |
| 700 | 1 | |a Gilski |D Miroslaw |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | |
| 700 | 1 | |a Kierzek |D Ryszard |u Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland |4 aut | |
| 700 | 1 | |a Lomozik |D Lechoslaw |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | |
| 700 | 1 | |a Jaskolski |D Mariusz |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 595-602 |x 0949-8257 |q 20:3<595 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1247-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1247-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Drozdzal |D Pawel |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gilski |D Miroslaw |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kierzek |D Ryszard |u Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lomozik |D Lechoslaw |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jaskolski |D Mariusz |u Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 595-602 |x 0949-8257 |q 20:3<595 |1 2015 |2 20 |o 775 | ||