caa a22 4500 605507287 CHVBK 20210128100631.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00775-015-1247-5 doi (NATIONALLICENCE)springer-10.1007/s00775-015-1247-5 High-resolution crystal structure of Z-DNA in complex with Cr3+ cations [Elektronische Daten] [Pawel Drozdzal, Miroslaw Gilski, Ryszard Kierzek, Lechoslaw Lomozik, Mariusz Jaskolski] This work is part of our project aimed at characterizing metal-binding properties of left-handed Z-DNA helices. The three Cr3+ cations found in the asymmetric unit of the d(CGCGCG)2-Cr3+ crystal structure do not form direct coordination bonds with atoms of the Z-DNA molecule. Instead, the hydrated Cr3+ ions are engaged in outer-sphere interactions with phosphate groups and O6 and N7 guanine atoms of the DNA. The Cr3+(1) and Cr3+(2) ions have disordered coordination spheres occupied by six water molecules each. These partial-occupancy chromium cations are 2.354(15)Å apart and are bridged by three water molecules from their hydration spheres. The Cr3+(3) cation has distorted square pyramidal geometry. In addition to the high degree of disorder of the DNA backbone, alternate conformations are also observed for the deoxyribose and base moieties of the G2 nucleotide. Our work illuminates the question of conformational flexibility of Z-DNA and its interaction mode with transition-metal cations. The Author(s), 2015 Z-DNA nationallicence Chromium nationallicence X-ray crystallography nationallicence Spm : Spermine nationallicence Spk : Sperminium tetracation nationallicence Put2+ : Putrescinium dication nationallicence Drozdzal Pawel Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut Gilski Miroslaw Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut Kierzek Ryszard Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland aut Lomozik Lechoslaw Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut Jaskolski Mariusz Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/3(2015-04-01), 595-602 0949-8257 20:3<595 2015 20 775 https://doi.org/10.1007/s00775-015-1247-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00775-015-1247-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Drozdzal Pawel Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Gilski Miroslaw Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Kierzek Ryszard Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland aut NATIONALLICENCE 700 1- Lomozik Lechoslaw Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Jaskolski Mariusz Faculty of Chemistry, A. Mickiewicz University, Umultowska 89b, 61-614, Poznan, Poland aut NATIONALLICENCE 773 0- JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/3(2015-04-01), 595-602 0949-8257 20:3<595 2015 20 775