Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N , N , N ′-trisubstituted thioureas
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1239-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1239-5 | ||
| 245 | 0 | 0 | |a Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N , N , N ′-trisubstituted thioureas |h [Elektronische Daten] |c [Muhammad Rauf, Samad Yaseen, Amin Badshah, Sumera Zaib, Raffia Arshad, Imtiaz-ud-Din,, Muhammad Tahir, Jamshed Iqbal] |
| 520 | 3 | |a A series of N,N,N′-trisubstituted thioureas (1-12) and their Ni(II) complexes (1a-12a) were synthesized and characterized by multinuclear (1H and 13C) NMR, FT-IR spectroscopy and LC-MS techniques in combination with elemental analysis. The crystal structures of both ligands and Ni(II) chelates of type Ni(L-O, S)2 were determined by single crystal X-ray diffraction analysis. All the complexes were adopted to have square planar geometry, where the N,N,N′-trisubstituted thioureas showed bidentate mode of coordination at nickel centre through oxygen and sulfur atoms. The synthesized complexes were screened for potential inhibitors of Jack bean urease. Compounds 1a and 3a were observed as most potent inhibitors of urease exhibiting IC50 values of 1.17±0.12 and 1.19±0.41µM, respectively. Cytotoxicity assay on lung carcinoma (H-157) and kidney fibroblast (BHK-21) cell showed that compounds were significant anticancer agents. Additionally, the complexes were tested against Leishmania major and found to be potent antileishmanial agents. | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a N , N , N ′-trisubstituted thioureas |2 nationallicence | |
| 690 | 7 | |a Nickel(II) complexes |2 nationallicence | |
| 690 | 7 | |a Urease inhibition |2 nationallicence | |
| 690 | 7 | |a Anticancer |2 nationallicence | |
| 690 | 7 | |a Antileishmanial |2 nationallicence | |
| 690 | 7 | |a ETDA : Ethylenediaminetetraacetic acid |2 nationallicence | |
| 690 | 7 | |a MTT : 3-(4 5-Dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide |2 nationallicence | |
| 690 | 7 | |a PBS : Phosphate-buffered saline |2 nationallicence | |
| 690 | 7 | |a SRB : Sulforhodamine B |2 nationallicence | |
| 690 | 7 | |a TCA : Trichloroacetic acid |2 nationallicence | |
| 690 | 7 | |a TLC : Thin layer chromatography |2 nationallicence | |
| 700 | 1 | |a Rauf |D Muhammad |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | |
| 700 | 1 | |a Yaseen |D Samad |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | |
| 700 | 1 | |a Badshah |D Amin |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | |
| 700 | 1 | |a Zaib |D Sumera |u Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan |4 aut | |
| 700 | 1 | |a Arshad |D Raffia |u Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan |4 aut | |
| 700 | 1 | |a Imtiaz-ud-Din, |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | |
| 700 | 1 | |a Tahir |D Muhammad |u Department of Physics, University of Sargodha, Sargodha, Pakistan |4 aut | |
| 700 | 1 | |a Iqbal |D Jamshed |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 541-554 |x 0949-8257 |q 20:3<541 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1239-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1239-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rauf |D Muhammad |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yaseen |D Samad |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Badshah |D Amin |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zaib |D Sumera |u Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arshad |D Raffia |u Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Imtiaz-ud-Din |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tahir |D Muhammad |u Department of Physics, University of Sargodha, Sargodha, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iqbal |D Jamshed |u Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 541-554 |x 0949-8257 |q 20:3<541 |1 2015 |2 20 |o 775 | ||