caa a22 4500 605507309 CHVBK 20210128100631.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00775-015-1239-5 doi (NATIONALLICENCE)springer-10.1007/s00775-015-1239-5 Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N , N , N ′-trisubstituted thioureas [Elektronische Daten] [Muhammad Rauf, Samad Yaseen, Amin Badshah, Sumera Zaib, Raffia Arshad, Imtiaz-ud-Din,, Muhammad Tahir, Jamshed Iqbal] A series of N,N,N′-trisubstituted thioureas (1-12) and their Ni(II) complexes (1a-12a) were synthesized and characterized by multinuclear (1H and 13C) NMR, FT-IR spectroscopy and LC-MS techniques in combination with elemental analysis. The crystal structures of both ligands and Ni(II) chelates of type Ni(L-O, S)2 were determined by single crystal X-ray diffraction analysis. All the complexes were adopted to have square planar geometry, where the N,N,N′-trisubstituted thioureas showed bidentate mode of coordination at nickel centre through oxygen and sulfur atoms. The synthesized complexes were screened for potential inhibitors of Jack bean urease. Compounds 1a and 3a were observed as most potent inhibitors of urease exhibiting IC50 values of 1.17±0.12 and 1.19±0.41µM, respectively. Cytotoxicity assay on lung carcinoma (H-157) and kidney fibroblast (BHK-21) cell showed that compounds were significant anticancer agents. Additionally, the complexes were tested against Leishmania major and found to be potent antileishmanial agents. SBIC, 2015 N , N , N ′-trisubstituted thioureas nationallicence Nickel(II) complexes nationallicence Urease inhibition nationallicence Anticancer nationallicence Antileishmanial nationallicence ETDA : Ethylenediaminetetraacetic acid nationallicence MTT : 3-(4 5-Dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide nationallicence PBS : Phosphate-buffered saline nationallicence SRB : Sulforhodamine B nationallicence TCA : Trichloroacetic acid nationallicence TLC : Thin layer chromatography nationallicence Rauf Muhammad Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut Yaseen Samad Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut Badshah Amin Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut Zaib Sumera Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan aut Arshad Raffia Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan aut Imtiaz-ud-Din, Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut Tahir Muhammad Department of Physics, University of Sargodha, Sargodha, Pakistan aut Iqbal Jamshed Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/3(2015-04-01), 541-554 0949-8257 20:3<541 2015 20 775 https://doi.org/10.1007/s00775-015-1239-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00775-015-1239-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rauf Muhammad Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Yaseen Samad Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Badshah Amin Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Zaib Sumera Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan aut NATIONALLICENCE 700 1- Arshad Raffia Centre for Advanced Drug Research, COMSATS Institute of Information Technology, 22060, Abbottabad, Pakistan aut NATIONALLICENCE 700 1- Imtiaz-ud-Din Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Tahir Muhammad Department of Physics, University of Sargodha, Sargodha, Pakistan aut NATIONALLICENCE 700 1- Iqbal Jamshed Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan aut NATIONALLICENCE 773 0- JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/3(2015-04-01), 541-554 0949-8257 20:3<541 2015 20 775