Interaction of apoNeuroglobin with heme-Aβ complexes relevant to Alzheimer's disease
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1241-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1241-y | ||
| 245 | 0 | 0 | |a Interaction of apoNeuroglobin with heme-Aβ complexes relevant to Alzheimer's disease |h [Elektronische Daten] |c [Manas Seal, Sheetal Uppal, Suman Kundu, Somdatta Dey] |
| 520 | 3 | |a Heme-Aβ complexes are known to produce toxic partially reduced oxygen species (PROS), catalyze oxidation of neurotransmitters and have been associated with Alzheimer's disease (AD). Neuroglobin (Ngb) play a crucial neuroprotective role against oxidative damage, hypoxic injuries, stroke and apoptosis of neuronal cells. In this study, the interaction of heme-Aβ with apoNeuroglobin (apoNgb) has been investigated using a combination of spectroscopic techniques. Absorption and resonance Raman data confirm that apoNgb can uptake heme from heme-Aβ and constitute a six-coordinate low-spin ferric heme-active site identical to that of Ngb. ApoNgb can also uptake heme from reduced heme-Aβ resulting in the formation of ferrous Ngb. The rate of the heme transfer reaction has been found to be of the order of 106M−1s−1. The reaction is faster for oxidized heme-Aβ than the reduced form. The amount of PROS formation by heme-Aβ complexes has been found to diminish drastically after reaction with apoNgb. ApoNgb can also sequester ligand-bound heme from heme-Aβ, e.g., the CO-bound heme from heme-Aβ-CO complex resulting in the formation of Ngb-CO complex. Additionally, ApoNgb can sequester heme from self-assembled monolayer (SAM) of surface-bound heme-Aβ formed over Au surface. This heme sequestration by apoNgb from heme-Aβ not only diminishes heme-induced toxicity but more significantly it produces Ngb which has well-documented neuroprotective role and can thereby potentially reduce risks associated with AD. Graphical Abstract: | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a Heme-Aβ |2 nationallicence | |
| 690 | 7 | |a ApoNeuroglobin |2 nationallicence | |
| 690 | 7 | |a Neuroglobin |2 nationallicence | |
| 690 | 7 | |a Alzheimer's disease |2 nationallicence | |
| 690 | 7 | |a PROS |2 nationallicence | |
| 700 | 1 | |a Seal |D Manas |u Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, 700032, Kolkata, India |4 aut | |
| 700 | 1 | |a Uppal |D Sheetal |u Department of Biochemistry, University of Delhi South Campus, 110021, New Delhi, India |4 aut | |
| 700 | 1 | |a Kundu |D Suman |u Department of Biochemistry, University of Delhi South Campus, 110021, New Delhi, India |4 aut | |
| 700 | 1 | |a Dey |D Somdatta |u Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, 700032, Kolkata, India |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 563-574 |x 0949-8257 |q 20:3<563 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1241-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1241-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Seal |D Manas |u Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, 700032, Kolkata, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Uppal |D Sheetal |u Department of Biochemistry, University of Delhi South Campus, 110021, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kundu |D Suman |u Department of Biochemistry, University of Delhi South Campus, 110021, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dey |D Somdatta |u Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, 700032, Kolkata, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/3(2015-04-01), 563-574 |x 0949-8257 |q 20:3<563 |1 2015 |2 20 |o 775 | ||