The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1260-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1260-8 | ||
| 245 | 0 | 4 | |a The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells |h [Elektronische Daten] |c [Laurent Sabater, Marie-Laure Nicolau-Travers, Aurore De Rache, Enora Prado, Jérôme Dejeu, Oriane Bombarde, Joris Lacroix, Patrick Calsou, Eric Defrancq, Jean-Louis Mergny, Dennis Gomez, Geneviève Pratviel] |
| 520 | 3 | |a With the aim of finding selective and biologically active G-quadruplex ligands, modified porphyrin with bulky cationic substituents, meso-5,10,15,20-tetrakis(4-guanidinophenyl)porphyrin tetrahydrochloride, referred to as guanidinium phenyl porphyrin, was prepared. The corresponding nickel(II) and cobalt(III) metallated porphyrins were also synthesized. Interaction with quadruplexes was examined by means of fluorescence resonance energy transfer melting and surface plasmon resonance-based assays: the three compounds proved to bind to G-quadruplex DNA in a similar and highly selective way. Guanidinium phenyl porphyrin and its nickel(II) metallated derivative exhibit moderate cytotoxicity toward cells in culture. Strikingly, the nickel porphyrin derivative was able to displace hPOT1 shelterin protein from telomeres in human cells. Graphical Abstract: Nickel(II) guanidinium phenyl porphyrin, a cationic bulky porphyrin is a powerful specific G-quadruplex DNA ligand. It enters the cells and induces shelterin modification. | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a G4 ligand |2 nationallicence | |
| 690 | 7 | |a Telomere |2 nationallicence | |
| 690 | 7 | |a Porphyrin |2 nationallicence | |
| 690 | 7 | |a G-quadruplex |2 nationallicence | |
| 690 | 7 | |a POT1 |2 nationallicence | |
| 700 | 1 | |a Sabater |D Laurent |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | |
| 700 | 1 | |a Nicolau-Travers |D Marie-Laure |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | |
| 700 | 1 | |a De Rache |D Aurore |u Laboratoire ARNA, Université de Bordeaux, 33000, Bordeaux, France |4 aut | |
| 700 | 1 | |a Prado |D Enora |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | |
| 700 | 1 | |a Dejeu |D Jérôme |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | |
| 700 | 1 | |a Bombarde |D Oriane |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | |
| 700 | 1 | |a Lacroix |D Joris |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | |
| 700 | 1 | |a Calsou |D Patrick |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | |
| 700 | 1 | |a Defrancq |D Eric |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | |
| 700 | 1 | |a Mergny |D Jean-Louis |u Laboratoire ARNA, Université de Bordeaux, 33000, Bordeaux, France |4 aut | |
| 700 | 1 | |a Gomez |D Dennis |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | |
| 700 | 1 | |a Pratviel |D Geneviève |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/4(2015-06-01), 729-738 |x 0949-8257 |q 20:4<729 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1260-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1260-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sabater |D Laurent |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nicolau-Travers |D Marie-Laure |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Rache |D Aurore |u Laboratoire ARNA, Université de Bordeaux, 33000, Bordeaux, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Prado |D Enora |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dejeu |D Jérôme |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bombarde |D Oriane |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lacroix |D Joris |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Calsou |D Patrick |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Defrancq |D Eric |u Université Grenoble Alpes, DCM, 38000, Grenoble, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mergny |D Jean-Louis |u Laboratoire ARNA, Université de Bordeaux, 33000, Bordeaux, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gomez |D Dennis |u Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pratviel |D Geneviève |u Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077, Toulouse, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/4(2015-06-01), 729-738 |x 0949-8257 |q 20:4<729 |1 2015 |2 20 |o 775 | ||