In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1310-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1310-2 | ||
| 245 | 0 | 0 | |a In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles |h [Elektronische Daten] |c [Shahanavaj Khan, Anees Ansari, Abdul Khan, Rehan Ahmad, Omar Al-Obaid, Wael Al-Kattan] |
| 520 | 3 | |a Cobalt oxide nanoparticles (Co3O4-NPs) were synthesized using simple urea-based thermal decomposition method. Phase purity and particle size of as-synthesized nanoparticles were characterized through X-ray diffraction pattern (XRD) and transmission electron microscopy. Through XRD morphology of the Co3O4-NPs was found to be variable in size with range of 36nm. In our present study, we explored the potential cytotoxic and antibacterial effects of Co3O4-NPs in human colorectal types of cancerous cells (HT29 and SW620) and also nine Gram-positive and Gram-negative bacteria. Co3O4-NPs showed promising anticancer activity against HT29 and SW620 cells with IC50 value of 2.26 and 394.5μg/mL, respectively. However, no significant effect of Co3O4-NPs was observed against bacterial strains. Furthermore, a detailed study has been carried out to investigate the possible mechanism of cell death in HT29 cancer cell line through the analysis of expression level of anti-apoptotic Bcl2 and BclxL markers. Western blot analysis results suggested significant role of Co3O4-NPs exposure in cell death due to apoptosis. Graphical Abstract: | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a Cobalt oxide nanoparticles |2 nationallicence | |
| 690 | 7 | |a MTT assay |2 nationallicence | |
| 690 | 7 | |a Cytotoxicity |2 nationallicence | |
| 690 | 7 | |a Western blot analysis |2 nationallicence | |
| 700 | 1 | |a Khan |D Shahanavaj |u Nanomedicine and Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, 11451, Riyadh, Saudi Arabia |4 aut | |
| 700 | 1 | |a Ansari |D Anees |u King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia |4 aut | |
| 700 | 1 | |a Khan |D Abdul |u Nanomedicine and Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, 11451, Riyadh, Saudi Arabia |4 aut | |
| 700 | 1 | |a Ahmad |D Rehan |u Colorectal Research Center, College of Medicine, King Saud University, 11451, Riyadh, Saudi Arabia |4 aut | |
| 700 | 1 | |a Al-Obaid |D Omar |u Colorectal Research Center, College of Medicine, King Saud University, 11451, Riyadh, Saudi Arabia |4 aut | |
| 700 | 1 | |a Al-Kattan |D Wael |u Department of Surgery, Al-Faisal University Riyadh, 11451, Riyadh, Saudi Arabia |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/8(2015-12-01), 1319-1326 |x 0949-8257 |q 20:8<1319 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1310-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1310-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khan |D Shahanavaj |u Nanomedicine and Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ansari |D Anees |u King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khan |D Abdul |u Nanomedicine and Biotechnology Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ahmad |D Rehan |u Colorectal Research Center, College of Medicine, King Saud University, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Al-Obaid |D Omar |u Colorectal Research Center, College of Medicine, King Saud University, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Al-Kattan |D Wael |u Department of Surgery, Al-Faisal University Riyadh, 11451, Riyadh, Saudi Arabia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/8(2015-12-01), 1319-1326 |x 0949-8257 |q 20:8<1319 |1 2015 |2 20 |o 775 | ||