4-(2′-Pyridyl)imidazole as an artificial nucleobase in highly stabilizing Ag(I)-mediated base pairs
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1274-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1274-2 | ||
| 245 | 0 | 0 | |a 4-(2′-Pyridyl)imidazole as an artificial nucleobase in highly stabilizing Ag(I)-mediated base pairs |h [Elektronische Daten] |c [Kristina Schweizer, Jutta Kösters, Jens Müller] |
| 520 | 3 | |a A new artificial nucleoside 2 comprising 4-(2′-pyridyl)imidazole as the nucleobase was devised and incorporated into a series of DNA oligonucleotide duplexes. The propensity of 2 to form metal-mediated homo and hetero base pairs was investigated in various 13mer and 26mer duplexes. The artificial nucleoside readily forms Ag(I)-mediated homo base pairs of the type 2-Ag(I)-2, in which the Ag(I) ion resides in a [2+2] coordination environment. In addition, the combination with the previously established imidazole nucleoside 1 leads to the formation of Ag(I)-mediated hetero base pairs (2-Ag(I)-1 and 1-Ag(I)-2) with a [2+1] coordination environment. With an increase in the melting temperature of ΔT m=21.8°C upon the formation of a Ag(I)-mediated base pair, the 2-Ag(I)-1 pair with the 13mer duplex is the most stabilizing Ag(I)-mediated base pair so far. Generally, the impact of the formation of a metal-mediated base pair on the properties of the DNA duplex was found to be significantly more prominent for shorter, intrinsically less stable duplexes. | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a DNA |2 nationallicence | |
| 690 | 7 | |a Metal-mediated base pair |2 nationallicence | |
| 690 | 7 | |a Silver |2 nationallicence | |
| 690 | 7 | |a Nucleic acid |2 nationallicence | |
| 700 | 1 | |a Schweizer |D Kristina |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | |
| 700 | 1 | |a Kösters |D Jutta |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | |
| 700 | 1 | |a Müller |D Jens |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/5(2015-07-01), 895-903 |x 0949-8257 |q 20:5<895 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1274-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1274-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schweizer |D Kristina |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kösters |D Jutta |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Müller |D Jens |u Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstr. 28/30, 48149, Münster, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/5(2015-07-01), 895-903 |x 0949-8257 |q 20:5<895 |1 2015 |2 20 |o 775 | ||