Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R=Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination
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| 024 | 7 | 0 | |a 10.1007/s00775-015-1271-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-015-1271-5 | ||
| 245 | 0 | 0 | |a Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R=Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination |h [Elektronische Daten] |c [Kah Ooi, Chien Yeo, Kok-Pian Ang, Abdah Akim, Yoke-Kqueen Cheah, Siti Halim, Hoi-Ling Seng, Edward Tiekink] |
| 520 | 3 | |a The phosphanegold(I) carbonimidothioates, Ph3PAu{SC(OR)=NC6H4Me-4} for R=Me (1), Et (2) and iPr (3), feature linear P-Au-S coordination geometries and exhibit potent in vitro cytotoxicity against HT-29 colon cancer cells in both monolayer and multi-cellular spheroid models (e.g., IC50=11.9±0.4 and 20.3±0.3μM for 2, respectively). Both intrinsic and extrinsic pathways of apoptosis are demonstrated by human apoptosis PCR array analysis, caspase activities, DNA fragmentation and cell apoptotic assays. Compounds 1-3 induce an extrinsic pathway that leads to down-regulation of NFκB. Compound 2 also exhibits an extrinsic apoptotic pathway involving the activation of both p53 and p73, whereas 3 activates p53 only. Lys48- and Lys63-linked polyubiquitination are also promoted by 1-3. Graphical abstract: Each of cytotoxic Ph3PAu{SC(OR)=NC6H4Me-4}, for R=Me (1), Et (2) and iPr (3), induce an intrinsic apoptotic pathway as well as an extrinsic pathway leading to down-regulation of NFκB. Lys48- and Lys63-linked polyubiquitination are promoted by 1-3 and these are able to inhibit cell invasion and to suppress the activity of TrxR. | |
| 540 | |a SBIC, 2015 | ||
| 690 | 7 | |a Gold(I) compounds |2 nationallicence | |
| 690 | 7 | |a Carbonimidothioates |2 nationallicence | |
| 690 | 7 | |a Phosphanegold thiolates |2 nationallicence | |
| 690 | 7 | |a Apoptosis |2 nationallicence | |
| 690 | 7 | |a Nuclear factor-κB activation pathway |2 nationallicence | |
| 700 | 1 | |a Ooi |D Kah |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 700 | 1 | |a Yeo |D Chien |u Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia |4 aut | |
| 700 | 1 | |a Ang |D Kok-Pian |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 700 | 1 | |a Akim |D Abdah |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 700 | 1 | |a Cheah |D Yoke-Kqueen |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 700 | 1 | |a Halim |D Siti |u Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia |4 aut | |
| 700 | 1 | |a Seng |D Hoi-Ling |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 700 | 1 | |a Tiekink |D Edward |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/5(2015-07-01), 855-873 |x 0949-8257 |q 20:5<855 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-015-1271-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-015-1271-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ooi |D Kah |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yeo |D Chien |u Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ang |D Kok-Pian |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akim |D Abdah |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cheah |D Yoke-Kqueen |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Halim |D Siti |u Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Seng |D Hoi-Ling |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tiekink |D Edward |u Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM, 43400, Serdang, Selangor Darul Ehsan, Malaysia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/5(2015-07-01), 855-873 |x 0949-8257 |q 20:5<855 |1 2015 |2 20 |o 775 | ||