Electronic structure contributions to reactivity in xanthine oxidase family enzymes
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| 024 | 7 | 0 | |a 10.1007/s00775-014-1212-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00775-014-1212-8 | ||
| 245 | 0 | 0 | |a Electronic structure contributions to reactivity in xanthine oxidase family enzymes |h [Elektronische Daten] |c [Benjamin Stein, Martin Kirk] |
| 520 | 3 | |a We review the xanthine oxidase (XO) family of pyranopterin molybdenum enzymes with a specific emphasis on electronic structure contributions to reactivity. In addition to xanthine and aldehyde oxidoreductases, which catalyze the two-electron oxidation of aromatic heterocycles and aldehyde substrates, this mini-review highlights recent work on the closely related carbon monoxide dehydrogenase (CODH) that catalyzes the oxidation of CO using a unique Mo-Cu heterobimetallic active site. A primary focus of this mini-review relates to how spectroscopy and computational methods have been used to develop an understanding of critical relationships between geometric structure, electronic structure, and catalytic function. | |
| 540 | |a SBIC, 2014 | ||
| 690 | 7 | |a Molybdenum |2 nationallicence | |
| 690 | 7 | |a Xanthine oxidase |2 nationallicence | |
| 690 | 7 | |a Carbon monoxide dehydrogenase |2 nationallicence | |
| 690 | 7 | |a Electronic structure |2 nationallicence | |
| 690 | 7 | |a Reactivity |2 nationallicence | |
| 690 | 7 | |a AO : Aldehyde oxidase |2 nationallicence | |
| 690 | 7 | |a CODH : CO dehydrogenase |2 nationallicence | |
| 690 | 7 | |a DFT : Density functional theory |2 nationallicence | |
| 690 | 7 | |a ENDOR : Electron-nuclear double resonance |2 nationallicence | |
| 690 | 7 | |a EPR : Electron paramagnetic resonance |2 nationallicence | |
| 690 | 7 | |a EXAFS : Extended X-ray absorption fine structure |2 nationallicence | |
| 690 | 7 | |a FAD : Flavin adenine dinucleotide |2 nationallicence | |
| 690 | 7 | |a MCD : Magnetic circular dichroism |2 nationallicence | |
| 690 | 7 | |a QM/MM : Quantum mechanics/molecular mechanics |2 nationallicence | |
| 690 | 7 | |a ROS : Reactive oxygen species |2 nationallicence | |
| 690 | 7 | |a rR : Resonance Raman |2 nationallicence | |
| 690 | 7 | |a XDH/XO/XOR : Xanthine dehydrogenase/oxidase/oxidoreductase |2 nationallicence | |
| 700 | 1 | |a Stein |D Benjamin |u Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, 300 Terrace St. NE, 87131, Albuquerque, NM, USA |4 aut | |
| 700 | 1 | |a Kirk |D Martin |u Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, 300 Terrace St. NE, 87131, Albuquerque, NM, USA |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/2(2015-03-01), 183-194 |x 0949-8257 |q 20:2<183 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-014-1212-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-014-1212-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stein |D Benjamin |u Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, 300 Terrace St. NE, 87131, Albuquerque, NM, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kirk |D Martin |u Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, 300 Terrace St. NE, 87131, Albuquerque, NM, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/2(2015-03-01), 183-194 |x 0949-8257 |q 20:2<183 |1 2015 |2 20 |o 775 | ||