Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout
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| 024 | 7 | 0 | |a 10.1007/s00775-014-1210-x |2 doi |
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| 245 | 0 | 0 | |a Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout |h [Elektronische Daten] |c [Takeshi Nishino, Ken Okamoto] |
| 520 | 3 | |a Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a key role in purine catabolism, catalyzing two steps of sequential hydroxylation from hypoxanthine to xanthine and from xanthine to urate at its molybdenum cofactor (Moco). Human XOR is considered to be a target of drugs not only for therapy of hyperuricemia and gout, but also potentially for a wide variety of other diseases. In this review, we focus on studies of XOR inhibitors and their implications for understanding the chemical nature and reaction mechanism of the Moco active site of XOR. We also discuss further experimental or clinical studies that would be helpful to clarify remaining issues. | |
| 540 | |a The Author(s), 2014 | ||
| 690 | 7 | |a Xanthine oxidase |2 nationallicence | |
| 690 | 7 | |a Uric acid |2 nationallicence | |
| 690 | 7 | |a Allopurinol |2 nationallicence | |
| 690 | 7 | |a Febuxostat |2 nationallicence | |
| 690 | 7 | |a Gout |2 nationallicence | |
| 700 | 1 | |a Nishino |D Takeshi |u Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Okamoto |D Ken |u Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan |4 aut | |
| 773 | 0 | |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/2(2015-03-01), 195-207 |x 0949-8257 |q 20:2<195 |1 2015 |2 20 |o 775 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00775-014-1210-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00775-014-1210-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishino |D Takeshi |u Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okamoto |D Ken |u Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t JBIC Journal of Biological Inorganic Chemistry |d Springer Berlin Heidelberg |g 20/2(2015-03-01), 195-207 |x 0949-8257 |q 20:2<195 |1 2015 |2 20 |o 775 | ||