caa a22 4500 605507864 CHVBK 20210128100634.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00775-014-1210-x doi (NATIONALLICENCE)springer-10.1007/s00775-014-1210-x Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout [Elektronische Daten] [Takeshi Nishino, Ken Okamoto] Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a key role in purine catabolism, catalyzing two steps of sequential hydroxylation from hypoxanthine to xanthine and from xanthine to urate at its molybdenum cofactor (Moco). Human XOR is considered to be a target of drugs not only for therapy of hyperuricemia and gout, but also potentially for a wide variety of other diseases. In this review, we focus on studies of XOR inhibitors and their implications for understanding the chemical nature and reaction mechanism of the Moco active site of XOR. We also discuss further experimental or clinical studies that would be helpful to clarify remaining issues. The Author(s), 2014 Xanthine oxidase nationallicence Uric acid nationallicence Allopurinol nationallicence Febuxostat nationallicence Gout nationallicence Nishino Takeshi Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan aut Okamoto Ken Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan aut JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/2(2015-03-01), 195-207 0949-8257 20:2<195 2015 20 775 https://doi.org/10.1007/s00775-014-1210-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00775-014-1210-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishino Takeshi Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan aut NATIONALLICENCE 700 1- Okamoto Ken Department of Biochemistry and Molecular Biology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, 113-8602, Tokyo, Japan aut NATIONALLICENCE 773 0- JBIC Journal of Biological Inorganic Chemistry Springer Berlin Heidelberg 20/2(2015-03-01), 195-207 0949-8257 20:2<195 2015 20 775