caa a22 4500 605509549 CHVBK 20210128100641.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10877-014-9589-z doi (NATIONALLICENCE)springer-10.1007/s10877-014-9589-z Repeated early hemofiltration filters clotting and heparin-induced thrombocytopenia in ICU [Elektronische Daten] [Sébastien Perbet, Thomas Godet, Aurélien Lebreton, Anne-Françoise Sapin, Jean-Michel Constantin] Repeated early hemofiltration filter clotting are real thrombotic events. Diagnosis of heparin-induced thrombocytopenia (HIT) in this setting in ICU remains difficult. We describe two cases of repeated early hemofiltration filters clotting in ICU and to evaluate their impact on the probability test 4T's score and diagnosis of HIT. Two patients undergoing at least three repeated early hemofiltration clotting filters in <6h revealing HIT in ICU had a low probability score for HIT. Despite a 4T's score of three for the two patients and persistent early hemofiltration clotting filters, functional tests for HIT antibodies (heparin induced platelet activation assay and serotonin release assay) were positive, permitting the diagnosis of HIT in both patients. We suggest that the occurrence of repeated, rapid (within 6h) hemofiltration filter clotting should score as two points for "Thrombosis” in the 4T's scoring system, thereby increasing the pretest probability for HIT in this clinical situation. Springer Science+Business Media New York, 2014 Heparin-induced thrombocytopenia nationallicence Hemofiltration nationallicence Anti-PF4 nationallicence Diagnosis nationallicence 4T's score nationallicence Perbet Sébastien CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut Godet Thomas CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut Lebreton Aurélien CHU Clermont-Ferrand, Hematology, University Hospital Estaing, Clermont-Ferrand, France aut Sapin Anne-Françoise CHU Clermont-Ferrand, Hematology, University Hospital Estaing, Clermont-Ferrand, France aut Constantin Jean-Michel CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/1(2015-02-01), 25-28 1387-1307 29:1<25 2015 29 10877 https://doi.org/10.1007/s10877-014-9589-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9589-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perbet Sébastien CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Godet Thomas CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Lebreton Aurélien CHU Clermont-Ferrand, Hematology, University Hospital Estaing, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Sapin Anne-Françoise CHU Clermont-Ferrand, Hematology, University Hospital Estaing, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Constantin Jean-Michel CHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/1(2015-02-01), 25-28 1387-1307 29:1<25 2015 29 10877