caa a22 4500 605509611 CHVBK 20210128100642.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10877-014-9580-8 doi (NATIONALLICENCE)springer-10.1007/s10877-014-9580-8 Analysis of heart rate variability during auditory stimulation periods in patients with schizophrenia [Elektronische Daten] [Saime Akar, Sadık Kara, Fatma Latifoğlu, Vedat Bilgiç] The vulnerability-stress model is a hypothesis for symptom development in schizophrenia patients who are generally characterized by cardiac autonomic dysfunction. Therefore, measures of heart rate variability (HRV) have been widely used in schizophrenics for assessing altered cardiac autonomic regulations. The goal of this study was to analyze HRV of schizophrenia patients and healthy control subjects with exposure to auditory stimuli. More specifically, this study examines whether schizophrenia patients may exhibit distinctive time and frequency domain parameters of HRV from control subjects during at rest and auditory stimulation periods. Photoplethysmographic signals were used in the analysis of HRV. Nineteen schizophrenic patients and twenty healthy control subjects were examined during rest periods, while exposed to periods of white noise (WN) and relaxing music. Results indicate that HRV in patients was lower than that of control subjects indicating autonomic dysfunction throughout the entire experiment. In comparison with control subjects, patients with schizophrenia exhibited lower high-frequency power and a higher low-frequency to high-frequency ratio. Moreover, while WN stimulus decreased parasympathetic activity in healthy subjects, no significant changes in heart rate and frequency-domain HRV parameters were observed between the auditory stimulation and rest periods in schizophrenia patients. We can conclude that HRV can be used as a sensitive index of emotion-related sympathetic activity in schizophrenia patients. Springer Science+Business Media New York, 2014 Photoplethysmography nationallicence Heart rate variability nationallicence Schizophrenia nationallicence Time and frequency domain analysis nationallicence Akar Saime Institute of Biomedical Engineering, Fatih University, 34500, Istanbul, Turkey aut Kara Sadık Institute of Biomedical Engineering, Fatih University, 34500, Istanbul, Turkey aut Latifoğlu Fatma Biomedical Engineering Department, Erciyes University, Kayseri, Turkey aut Bilgiç Vedat Department of Psychiatry, Faculty of Medicine, Fatih University, Istanbul, Turkey aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/1(2015-02-01), 153-162 1387-1307 29:1<153 2015 29 10877 https://doi.org/10.1007/s10877-014-9580-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9580-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akar Saime Institute of Biomedical Engineering, Fatih University, 34500, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kara Sadık Institute of Biomedical Engineering, Fatih University, 34500, Istanbul, Turkey aut NATIONALLICENCE 700 1- Latifoğlu Fatma Biomedical Engineering Department, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Bilgiç Vedat Department of Psychiatry, Faculty of Medicine, Fatih University, Istanbul, Turkey aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/1(2015-02-01), 153-162 1387-1307 29:1<153 2015 29 10877