caa a22 4500 605509859 CHVBK 20210128100643.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10877-015-9668-9 doi (NATIONALLICENCE)springer-10.1007/s10877-015-9668-9 Validation of stroke volume and cardiac output by electrical interrogation of the brachial artery in normals: assessment of strengths, limitations, and sources of error [Elektronische Daten] [Donald Bernstein, Isaac Henry, Harry Lemmens, Janell Chaltas, Anthony DeMaria, James Moon, Andrew Kahn] The goal of this study is to validate a new, continuous, noninvasive stroke volume (SV) method, known as transbrachial electrical bioimpedance velocimetry (TBEV). TBEV SV was compared to SV obtained by cardiac magnetic resonance imaging (cMRI) in normal humans devoid of clinically apparent heart disease. Thirty-two (32) volunteers were enrolled in the study. Each subject was evaluated by echocardiography to assure that no aortic or mitral valve disease was present. Subsequently, each subject underwent electrical interrogation of the brachial artery by means of a high frequency, low amplitude alternating current. A first TBEV SV estimate was obtained. Immediately after the initial TBEV study, subjects underwent cMRI, using steady-state precession imaging to obtain a volumetric estimate of SV. Following cMRI, the TBEV SV study was repeated. Comparing the cMRI-derived SV to that of TBEV, the two TBEV estimates were averaged and compared to the cMRI standard. CO was computed as the product of SV and heart rate. Statistical methods consisted of Bland-Altman and linear regression analysis. TBEV SV and CO estimates were obtained in 30 of the 32 subjects enrolled. Bland-Altman analysis of pre- and post-cMRI TBEV SV showed a mean bias of 2.87 % (2.05mL), precision of 13.59% (11.99mL) and 95% limits of agreement (LOA) of +29.51% (25.55mL) and −23.77% (−21.45mL). Regression analysis for pre- and post-cMRI TBEV SV values yielded y=0.76x+25.1 and r2=0.71 (r=0.84). Bland-Altman analysis comparing cMRI SV with averaged TBEV SV showed a mean bias of −1.56% (−1.53mL), precision of 13.47% (12.84mL), 95% LOA of +24.85% (+23.64mL) and −27.97% (−26.7mL) and percent error=26.2%. For correlation analysis, the regression equation was y=0.82x+19.1 and correlation coefficient r2=0.61 (r=0.78). Bland-Altman analysis of averaged pre- and post-cMRI TBEV CO versus cMRI CO yielded a mean bias of 5.01% (0.32Lmin−1), precision of 12.85% (0.77Lmin−1), 95% LOA of +30.20% (+0.1.83Lmin−1) and −20.7% (−1.19Lmin−1) and percent error=24.8%. Regression analysis yielded y=0.92x+0.78, correlation coefficient r2=0.74 (r=0.86). TBEV is a novel, noninvasive method, which provides satisfactory estimates of SV and CO in normal humans. The Author(s), 2015 Stroke volume nationallicence Cardiac output nationallicence Noninvasive nationallicence Transbrachial electrical velocimetry nationallicence Impedance cardiography nationallicence Bernstein Donald Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut Henry Isaac Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut Lemmens Harry Department of Anesthesia, Stanford University School of Medicine, 94305-5115, Stanford, CA, USA aut Chaltas Janell Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut DeMaria Anthony Department of Medicine, University of California San Diego School of Medicine, 92103, San Diego, CA, USA aut Moon James Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut Kahn Andrew Department of Medicine, University of California San Diego School of Medicine, 92103, San Diego, CA, USA aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 789-800 1387-1307 29:6<789 2015 29 10877 https://doi.org/10.1007/s10877-015-9668-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-015-9668-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bernstein Donald Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut NATIONALLICENCE 700 1- Henry Isaac Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut NATIONALLICENCE 700 1- Lemmens Harry Department of Anesthesia, Stanford University School of Medicine, 94305-5115, Stanford, CA, USA aut NATIONALLICENCE 700 1- Chaltas Janell Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut NATIONALLICENCE 700 1- DeMaria Anthony Department of Medicine, University of California San Diego School of Medicine, 92103, San Diego, CA, USA aut NATIONALLICENCE 700 1- Moon James Sotera Wireless, Inc., 10020 Huennekens Street, 92121, San Diego, CA, USA aut NATIONALLICENCE 700 1- Kahn Andrew Department of Medicine, University of California San Diego School of Medicine, 92103, San Diego, CA, USA aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 789-800 1387-1307 29:6<789 2015 29 10877