caa a22 4500 605509875 CHVBK 20210128100643.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10877-015-9662-2 doi (NATIONALLICENCE)springer-10.1007/s10877-015-9662-2 Evaluation of near-infrared spectroscopy under apnea-dependent hypoxia in humans [Elektronische Daten] [Lars Eichhorn, Felix Erdfelder, Florian Kessler, Jonas Doerner, Marcus Thudium, Rainer Meyer, Richard Ellerkmann] In this study we investigated the responsiveness of near-infrared spectroscopy (NIRS) recordings measuring regional cerebral tissue oxygenation (rSO2) during hypoxia in apneic divers. The goal was to mimic dynamic hypoxia as present during cardiopulmonary resuscitation, laryngospasm, airway obstruction, or the "cannot ventilate cannot intubate” situation. Ten experienced apneic divers performed maximal breath hold maneuvers under dry conditions. SpO2 was measured by Masimo™ pulse oximetry on the forefinger of the left hand. NIRS was measured by NONIN Medical's EQUANOX™ on the forehead or above the musculus quadriceps femoris. Following apnea median cerebral rSO2 and SpO2 values decreased significantly from 71 to 54 and from 100 to 65%, respectively. As soon as cerebral rSO2 and SpO2 values decreased monotonically the correlation between normalized cerebral rSO2 and SpO2 values was highly significant (Pearson correlation coefficient=0.893). Prior to correlation analyses, the values were normalized by dividing them by the individual means of stable pre-apneic measurements. Cerebral rSO2 measured re-saturation after termination of apnea significantly earlier (10s, SD=3.6s) compared to SpO2 monitoring (21s, SD=4.4s) [t(9)=7.703, p<0.001, r2=0.868]. Our data demonstrate that NIRS monitoring reliably measures dynamic changes in cerebral tissue oxygen saturation, and identifies successful re-saturation faster than SpO2. Measuring cerebral rSO2 may prove beneficial in case of respiratory emergencies and during pulseless situations where SpO2 monitoring is impossible. Springer Science+Business Media New York, 2015 Hypoxia nationallicence NIRS nationallicence rSO2 nationallicence SpO2 nationallicence Apnea nationallicence Eichhorn Lars Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut Erdfelder Felix Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut Kessler Florian Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut Doerner Jonas Department of Radiology, University Hospital Bonn, Bonn, Germany aut Thudium Marcus Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut Meyer Rainer Institute of Physiology 2, University of Bonn, Bonn, Germany aut Ellerkmann Richard Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 749-757 1387-1307 29:6<749 2015 29 10877 https://doi.org/10.1007/s10877-015-9662-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-015-9662-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eichhorn Lars Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Erdfelder Felix Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Kessler Florian Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Doerner Jonas Department of Radiology, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Thudium Marcus Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Meyer Rainer Institute of Physiology 2, University of Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Ellerkmann Richard Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 749-757 1387-1307 29:6<749 2015 29 10877