caa a22 4500 605509964 CHVBK 20210128100643.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10877-015-9663-1 doi (NATIONALLICENCE)springer-10.1007/s10877-015-9663-1 Early monitoring of ventriculostomy-related infections with procalcitonin in patients with ventricular drains [Elektronische Daten] [Amr Omar, Amr ElShawarby, Rajvir Singh] Several factors are implicated in the increased vulnerability of multiple trauma victims to infection, especially in intensive care units. The incidence of EVD related infections ranges from 5 to 20%. To assess the accuracy of serum procalcitonin (PCT) in predicting central nervous system (CNS) infection in patients with EVDs. Thirty-six adult patients with severe head trauma were enrolled in this prospective study, after exclusion of other causes of fever; patients were subjected to sampling of C-reactive protein (CRP), PCT, and cerebrospinal fluid (CSF) cultures every other day. Five patients developed ventriculostomy-related infections, and all had an elevated serum PCT concentration. Patients with negative CSF cultures had mean serum PCT <2.0ng/ml, while patients with positive culture had early elevation of serum PCT with mean of 4.18ng/ml, CRP did not show similar early changes. Patients who acquire CNS infection had prolonged length of stay in hospital and length of ventilation. In absence of other nosocomial infections, early high serum PCT concentrations appear to be a reliable indicator of bacterial CNS infection in patients with EVD. Springer Science+Business Media New York, 2015 Procacitonin nationallicence External ventricular drain nationallicence Meningitis nationallicence APACHE II : Acute physiology and chronic health evaluation score II nationallicence CDC : Centers for Disease Control and Prevention nationallicence CNS : Central nervous system nationallicence CSF : Cerebrospinal fluid nationallicence CRP : C-reactive protein nationallicence DC : Decompressive craniectomy nationallicence ECL : Electrochemiluminescence nationallicence EVD : External ventricular drain nationallicence GCS : Glasgow coma scale nationallicence ICP : Intracranial pressure nationallicence ICU : Intensive care unit nationallicence ICULOS : Length of stay in ICU nationallicence ICULOV : Length of ventilation in ICU nationallicence MRSA : Methicillin-resistant staphylococcus aureus nationallicence PCT : Procalcitonin nationallicence Tmax : Maximum temperature nationallicence WBC : White blood cell count nationallicence Omar Amr Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar aut ElShawarby Amr Tawam Hospital, Abu Dhabi, UAE aut Singh Rajvir Biostatistics, Medial Research Department, Hamad Medical Corporation, Doha, Qatar aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 759-765 1387-1307 29:6<759 2015 29 10877 https://doi.org/10.1007/s10877-015-9663-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-015-9663-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Omar Amr Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar aut NATIONALLICENCE 700 1- ElShawarby Amr Tawam Hospital, Abu Dhabi, UAE aut NATIONALLICENCE 700 1- Singh Rajvir Biostatistics, Medial Research Department, Hamad Medical Corporation, Doha, Qatar aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/6(2015-12-01), 759-765 1387-1307 29:6<759 2015 29 10877