Comprehensive diagnosis of whole-body acid-base and fluid-electrolyte disorders using a mathematical model and whole-body base excess
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| 024 | 7 | 0 | |a 10.1007/s10877-014-9625-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10877-014-9625-z | ||
| 100 | 1 | |a Wolf |D Matthew |u Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 29209, Columbia, SC, USA |4 aut | |
| 245 | 1 | 0 | |a Comprehensive diagnosis of whole-body acid-base and fluid-electrolyte disorders using a mathematical model and whole-body base excess |h [Elektronische Daten] |c [Matthew Wolf] |
| 520 | 3 | |a A mathematical model of whole-body acid-base and fluid-electrolyte balance was used to provide information leading to the diagnosis and fluid-therapy treatment in patients with complex acid-base disorders. Given a set of measured laboratory-chemistry values for a patient, a model of their unique, whole-body chemistry was created. This model predicted deficits or excesses in the masses of Na+, K+, Cl− and H2O as well as the plasma concentration of unknown or unmeasured species, such as ketoacids, in diabetes mellitus. The model further characterized the acid-base disorder by determining the patient's whole-body base excess and quantitatively partitioning it into ten components, each contributing to the overall disorder. The results of this study showed the importance of a complete set of laboratory measurements to obtain sufficient accuracy of the quantitative diagnosis; having only a minimal set, just pH and PCO2, led to a large scatter in the predicted results. A computer module was created that would allow a clinician to achieve this diagnosis at the bedside. This new diagnostic approach should prove to be valuable in the treatment of the critically ill. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Acid-base balance |2 nationallicence | |
| 690 | 7 | |a Fluid-electrolyte balance |2 nationallicence | |
| 690 | 7 | |a Whole-body base excess |2 nationallicence | |
| 690 | 7 | |a Metabolic acidosis |2 nationallicence | |
| 690 | 7 | |a Bicarbonate space |2 nationallicence | |
| 690 | 7 | |a Mathematical model |2 nationallicence | |
| 690 | 7 | |a Atot : Electrical charge of plasma "weak” ions (mEq/lP) |2 nationallicence | |
| 690 | 7 | |a ABS : Apparent bicarbonate space (lP/kg) |2 nationallicence | |
| 690 | 7 | |a AG : Anion gap (mEq/lP) |2 nationallicence | |
| 690 | 7 | |a AGadj : AG adjusted for albumin effect |2 nationallicence | |
| 690 | 7 | |a AGc : AG corrected for albumin and Pi effects |2 nationallicence | |
| 690 | 7 | |a Alb : Serum albumin |2 nationallicence | |
| 690 | 7 | |a B : Blood |2 nationallicence | |
| 690 | 7 | |a BE : Base excess (mEq/l) |2 nationallicence | |
| 690 | 7 | |a BS : Bicarbonate space (lP/kg) |2 nationallicence | |
| 690 | 7 | |a CIPE : Refers to cell-interstitial-plasma-erythrocyte model compartments |2 nationallicence | |
| 690 | 7 | |a E : Erythrocyte |2 nationallicence | |
| 690 | 7 | |a ECF : Extracellular fluid |2 nationallicence | |
| 690 | 7 | |a Ht : Height (cm) |2 nationallicence | |
| 690 | 7 | |a IPE : Refers to interstitial-plasma-erythrocyte model compartments |2 nationallicence | |
| 690 | 7 | |a Hb : Hemoglobin |2 nationallicence | |
| 690 | 7 | |a I : Interstitial |2 nationallicence | |
| 690 | 7 | |a LBM : Lean body mass (kg) |2 nationallicence | |
| 690 | 7 | |a M : Mass (mmol) |2 nationallicence | |
| 690 | 7 | |a MZ : Mass times electrical valence (mEq) |2 nationallicence | |
| 690 | 7 | |a P : Plasma |2 nationallicence | |
| 690 | 7 | |a Pi− : Phosphate ions |2 nationallicence | |
| 690 | 7 | |a SBE : Standard base excess (mEq/lB+ECF) |2 nationallicence | |
| 690 | 7 | |a SID : Strong ion difference (mEq/lP) |2 nationallicence | |
| 690 | 7 | |a SIG : Strong ion gap (mEq/lP) |2 nationallicence | |
| 690 | 7 | |a QDV : Quantitative diagnostic variable |2 nationallicence | |
| 690 | 7 | |a Wt : Weight (kg) |2 nationallicence | |
| 690 | 7 | |a WBBE : Whole-body base excess (mEq/kg) |2 nationallicence | |
| 690 | 7 | |a XA− : Net charge of undetermined or unmeasured ions in plasma (mEq/lP) |2 nationallicence | |
| 690 | 7 | |a a : Arterial |2 nationallicence | |
| 690 | 7 | |a v : Venous |2 nationallicence | |
| 690 | 7 | |a [i] : Concentration of species i |2 nationallicence | |
| 690 | 7 | |a Δ : Change |2 nationallicence | |
| 773 | 0 | |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/4(2015-08-01), 475-490 |x 1387-1307 |q 29:4<475 |1 2015 |2 29 |o 10877 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10877-014-9625-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10877-014-9625-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Wolf |D Matthew |u Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 29209, Columbia, SC, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/4(2015-08-01), 475-490 |x 1387-1307 |q 29:4<475 |1 2015 |2 29 |o 10877 | ||