caa a22 4500 605510180 CHVBK 20210128100644.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10877-015-9680-0 doi (NATIONALLICENCE)springer-10.1007/s10877-015-9680-0 Pulse transit time shows vascular changes caused by propofol in children [Elektronische Daten] [Joo-Eun Kang, In-Kyung Song, Ji-Hyun Lee, Min Hur, Jin-Tae Kim, Hee-Soo Kim] Pulse transit time (PTT) is the time that it takes for the arterial pulse pressure wave to travel from the aortic valve to the periphery. It is a simple noninvasive technique for evaluating vascular changes. This study investigated the vascular changes by propofol during the induction of anesthesia in pediatric patients with the measuring of PTT. Without premedication, 2mg/kg of propofol was administered intravenously with monitoring of electrocardiogram (ECG) and photoplethysmograph (PPG) in 20 pediatric patients aged 3-7years. The ECG and PPG data were obtained for 1min before propofol injection (baseline PTT) and 2min after administration of propofol in the operating room. The PTT was defined as the time interval from the R-wave on the ECG to the maximum upslope of the corresponding PPG. The PTT was calculated off-line after collecting the data. The mean baseline PTT was 166.2±25.9ms and maximum PTT after propofol injection was 315.9±64.9ms (the interval between injection and the peak was 17.3±7.6s). The PTT after the peak changed variously; most of the patients showed no plateau; the PTT decreased progressively after the peak. The PTT after propofol administration prolonged in short time and rapidly recovered toward to the baseline values in pediatric patients. In conclusion, the baseline PTT in children is shorter comparing with adults and the vasodilatory effect of propofol on the vessels as described by the PTT was rapid and the recovery was faster, although the response to propofol was more varied than in adults. Springer Science+Business Media New York, 2015 Children nationallicence Propofol nationallicence Pulse transit time nationallicence Kang Joo-Eun Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Song In-Kyung Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Lee Ji-Hyun Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Hur Min Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Kim Jin-Tae Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Kim Hee-Soo Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/4(2015-08-01), 533-537 1387-1307 29:4<533 2015 29 10877 https://doi.org/10.1007/s10877-015-9680-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-015-9680-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Joo-Eun Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Song In-Kyung Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Ji-Hyun Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Hur Min Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Jin-Tae Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Hee-Soo Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/4(2015-08-01), 533-537 1387-1307 29:4<533 2015 29 10877