Hypoxic guard systems do not prevent rapid hypoxic inspired mixture formation
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| 024 | 7 | 0 | |a 10.1007/s10877-014-9626-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10877-014-9626-y | ||
| 245 | 0 | 0 | |a Hypoxic guard systems do not prevent rapid hypoxic inspired mixture formation |h [Elektronische Daten] |c [Sofie De Cooman, Caroline Schollaert, Jan Hendrickx, Philip Peyton, Tom Van Zundert, Andre De Wolf] |
| 520 | 3 | |a Because a case report and theoretical mass balances suggested that hypoxic guard systems may not prevent the formation of hypoxic inspired mixtures (FIO2≤21%) over the clinically used fresh gas flow (FGF) range, we measured FIO2 over a wide range of hypoxic guard limits for O2/N2O and O2/air mixtures. After IRB approval, 16 ASA I-II patients received sevoflurane in either O2/N2O (n=8) or O2/air (n=8) using a Zeus® anesthesia machine in the conventional mode. After using an 8L/min FGF with FDO2=25% for 10min, the following hypoxic guard limits were tested for 4min each, expressed as [total FGF in L/min; FDO2 in %]: [0.3;85], [0.4;65], [0.5;50], [0.7;36], [0.85;30], [1.0;25], [1.25;25], [1.5;25], [2;25], [3;25], [5;25], and [8;25]. In between these [FGF;FDO2] combinations, 8L/min FGF with 25% O2 was used for 4min to return to the same baseline FIO2 (25%) before the start of the next combination. This sequence was studied once in each patient receiving O2/air (n=8), but twice in each patient who received O2/N2O (n=8) to examine the effect of decreasing N2O uptake over time, resulting in three groups: early O2/N2O, late O2/N2O, and O2/air group. The [FGF;FDO2]-FIO2 relationship was examined. The overall [FGF;FDO2]-FIO2 relationship in the three groups was similar. In all 1, 1.25, and 1.5L/min FGF groups, FIO2 decreased below 21% in all but one patient; this occurred within 1min in at least one patient. In the 0.7L/min O2/air group and the 3L/min late O2/N2O and O2/air groups, FIO2 decreased below 21% in one patient. Current hypoxic guard systems do not reliably prevent a hypoxic FIO2 with O2/N2O and O2/air mixtures, particularly between 0.7 and 3L/min. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Machine standards |2 nationallicence | |
| 690 | 7 | |a Hypoxic guard system |2 nationallicence | |
| 690 | 7 | |a Hypoxia |2 nationallicence | |
| 690 | 7 | |a Hypoxic mixtures |2 nationallicence | |
| 690 | 7 | |a Rebreathing |2 nationallicence | |
| 700 | 1 | |a De Cooman |D Sofie |u Department of Anaesthesia, Kliniek Sint-Jan, Brussels, Belgium |4 aut | |
| 700 | 1 | |a Schollaert |D Caroline |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | |
| 700 | 1 | |a Hendrickx |D Jan |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | |
| 700 | 1 | |a Peyton |D Philip |u Department of Anaesthesia, Austin Hospital, University of Melbourne, Parkville, Australia |4 aut | |
| 700 | 1 | |a Van Zundert |D Tom |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | |
| 700 | 1 | |a De Wolf |D Andre |u Department of Anaesthesia, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA |4 aut | |
| 773 | 0 | |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/4(2015-08-01), 491-497 |x 1387-1307 |q 29:4<491 |1 2015 |2 29 |o 10877 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10877-014-9626-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10877-014-9626-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Cooman |D Sofie |u Department of Anaesthesia, Kliniek Sint-Jan, Brussels, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schollaert |D Caroline |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hendrickx |D Jan |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Peyton |D Philip |u Department of Anaesthesia, Austin Hospital, University of Melbourne, Parkville, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Van Zundert |D Tom |u Department of Anaesthesia, Intensive Care and Pain Therapy, OLV Hospital, Moorselbaan 164, 9300, Aalst, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De Wolf |D Andre |u Department of Anaesthesia, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/4(2015-08-01), 491-497 |x 1387-1307 |q 29:4<491 |1 2015 |2 29 |o 10877 | ||