Hemodynamic volumetry using transpulmonary ultrasound dilution (TPUD) technology in a neonatal animal model
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| 024 | 7 | 0 | |a 10.1007/s10877-014-9647-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10877-014-9647-6 | ||
| 245 | 0 | 0 | |a Hemodynamic volumetry using transpulmonary ultrasound dilution (TPUD) technology in a neonatal animal model |h [Elektronische Daten] |c [Sabine Vrancken, Arno van Heijst, Jeroen Hopman, Kian Liem, Johannes van der Hoeven, Willem de Boode] |
| 520 | 3 | |a To analyze changes in cardiac output and hemodynamic volumes using transpulmonary ultrasound dilution (TPUD) in a neonatal animal model under different hemodynamic conditions. 7 lambs (3.5-8.3kg) under general anesthesia received arterial and central venous catheters. A Gore-Tex® shunt was surgically inserted between the descending aortaand the left pulmonary artery to mimic a patent ductus arteriosus. After shunt opening and closure, induced hemorrhagic hypotension (by repetitive blood withdrawals) and repetitive volume challenges, the following parameters were assessed using TPUD: cardiac output, active circulating volume index (ACVI), central blood volume index (CBVI) and total end-diastolic volume index (TEDVI). 27 measurement sessions were analyzed. After shunt opening, there was a significant increase in TEDVI and a significant decrease in cardiac output with minimal change in CBVI and ACVI. With shunt closure, these results reversed. After progressive hemorrhage, cardiac output and all volumes decreased significantly, except for ACVI. Following repetitive volume resuscitation, cardiac output increased and all hemodynamic volumes increased significantly. Correlations between changes in COufp and changes in hemodynamic volumes (ACVI 0.83; CBVI 0.84 and TEDVI 0.78 respectively) were (slightly) better than between changes in COufp and changes in heart rate (0.44) and central venous pressure (0.7). Changes in hemodynamic volumes using TPUD were as expected under different conditions. Hemodynamic volumetry using TPUD might be a promising technique that has the potential to improve the assessment and interpretation of the hemodynamic status in critically ill newborns and children. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Child |2 nationallicence | |
| 690 | 7 | |a Infant |2 nationallicence | |
| 690 | 7 | |a Newborn |2 nationallicence | |
| 690 | 7 | |a Cardiac output |2 nationallicence | |
| 690 | 7 | |a Transpulmonary ultrasound dilution technique |2 nationallicence | |
| 690 | 7 | |a Ductus arteriosus |2 nationallicence | |
| 690 | 7 | |a Hemodynamic volumes |2 nationallicence | |
| 690 | 7 | |a ACV(I) : Active circulating volume (index) |2 nationallicence | |
| 690 | 7 | |a AV-loop : Arteriovenous loop |2 nationallicence | |
| 690 | 7 | |a CBV(I) : Central blood volume (index) |2 nationallicence | |
| 690 | 7 | |a COtpud : Cardiac output measured by transpulmonary ultrasound dilution |2 nationallicence | |
| 690 | 7 | |a COufp : Systemic blood flow/cardiac output measured by ultrasonic transit-time flow probe |2 nationallicence | |
| 690 | 7 | |a CVP : Central venous pressure |2 nationallicence | |
| 690 | 7 | |a GEDV(I) : Global end-diastolic volume (index) |2 nationallicence | |
| 690 | 7 | |a ITBV(I) : Intrathoracic blood volume (index) |2 nationallicence | |
| 690 | 7 | |a MAP : Mean arterial blood pressure |2 nationallicence | |
| 690 | 7 | |a TEDV(I) : Total end-diastolic volume (index) |2 nationallicence | |
| 690 | 7 | |a TPUD : Transpulmonary ultrasound dilution |2 nationallicence | |
| 690 | 7 | |a TPTD : Transpulmonary thermodilution |2 nationallicence | |
| 690 | 7 | |a QAOpre : Blood flow proximal to the insertion of aortopulmonary shunt |2 nationallicence | |
| 690 | 7 | |a QAOpost : Blood flow distal to the insertion of aortopulmonary shunt |2 nationallicence | |
| 700 | 1 | |a Vrancken |D Sabine |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a van Heijst |D Arno |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a Hopman |D Jeroen |u Department of Radiology, Medical Ultrasound Imaging Centre, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a Liem |D Kian |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a van der Hoeven |D Johannes |u Department of Pediatric Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a de Boode |D Willem |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | |
| 773 | 0 | |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/5(2015-10-01), 643-652 |x 1387-1307 |q 29:5<643 |1 2015 |2 29 |o 10877 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10877-014-9647-6 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10877-014-9647-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vrancken |D Sabine |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Heijst |D Arno |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hopman |D Jeroen |u Department of Radiology, Medical Ultrasound Imaging Centre, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liem |D Kian |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Hoeven |D Johannes |u Department of Pediatric Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Boode |D Willem |u Division of Neonatology, Department of Pediatrics, Radboud University Nijmegen Medical Center, Internal Postal Code 804, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Clinical Monitoring and Computing |d Springer Netherlands |g 29/5(2015-10-01), 643-652 |x 1387-1307 |q 29:5<643 |1 2015 |2 29 |o 10877 | ||