caa a22 4500 605510296 CHVBK 20210128100645.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10877-014-9638-7 doi (NATIONALLICENCE)springer-10.1007/s10877-014-9638-7 Monitoring CO2 in shock states [Elektronische Daten] [Pierre-Eric Danin, Nils Siegenthaler, Jacques Levraut, Gilles Bernardin, Jean Dellamonica, Karim Bendjelid] The primary end point when treating acute shock is to restore blood circulation, mainly by reaching macrocirculatory parameters. However, even if global haemodynamic goals can be achieved, microcirculatory perfusion may remain impaired, leading to cellular hypoxia and organ damage. Interestingly, few methods are currently available to measure the adequacy of organ blood flow and tissue oxygenation. The rise in tissue partial pressure of carbon dioxide (CO2) has been observed when tissue perfusion is decreased. In this regard, tissue partial pressure of CO2 has been proposed as an early and reliable marker of tissue hypoxia even if the mechanisms of tissue partial pressure in CO2 rise during hypoperfusion remain unclear. Several technologies allow the estimation of CO2 content from different body sites: vascular, tissular (in hollow organs, mucosal or cutaneous), and airway. These tools remain poorly evaluated, and some are used but are not widely used in clinical practice. The present review clarifies the physiology of increasing tissue CO2 during hypoperfusion and underlines the specificities of the different technologies that allow bedside estimation of tissue CO2 content. Springer Science+Business Media New York, 2014 Shock nationallicence Microcirculation nationallicence Carbon dioxide nationallicence Tissue hypoxia nationallicence Intensive care nationallicence Danin Pierre-Eric Medical Intensive Care, Nice University Hospital, Nice, France aut Siegenthaler Nils Intensive Care Division, Geneva University Hospitals, Geneva, Switzerland aut Levraut Jacques Emergency Department, Nice University Hospital, Nice, France aut Bernardin Gilles Medical Intensive Care, Nice University Hospital, Nice, France aut Dellamonica Jean Medical Intensive Care, Nice University Hospital, Nice, France aut Bendjelid Karim Intensive Care Division, Geneva University Hospitals, Geneva, Switzerland aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 591-600 1387-1307 29:5<591 2015 29 10877 https://doi.org/10.1007/s10877-014-9638-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9638-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Danin Pierre-Eric Medical Intensive Care, Nice University Hospital, Nice, France aut NATIONALLICENCE 700 1- Siegenthaler Nils Intensive Care Division, Geneva University Hospitals, Geneva, Switzerland aut NATIONALLICENCE 700 1- Levraut Jacques Emergency Department, Nice University Hospital, Nice, France aut NATIONALLICENCE 700 1- Bernardin Gilles Medical Intensive Care, Nice University Hospital, Nice, France aut NATIONALLICENCE 700 1- Dellamonica Jean Medical Intensive Care, Nice University Hospital, Nice, France aut NATIONALLICENCE 700 1- Bendjelid Karim Intensive Care Division, Geneva University Hospitals, Geneva, Switzerland aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 591-600 1387-1307 29:5<591 2015 29 10877