caa a22 4500 605510369 CHVBK 20210128100645.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10877-014-9631-1 doi (NATIONALLICENCE)springer-10.1007/s10877-014-9631-1 Noninvasive assessment of peripheral microcirculation by near-infrared spectroscopy: a comparative study in healthy smoking and nonsmoking volunteers [Elektronische Daten] [Guillaume Zamparini, Géraldine Butin, Marc-Olivier Fischer, Jean-Louis Gérard, Jean-Luc Hanouz, Jean-Luc Fellahi] Smokers are exposed to early endothelial dysfunction. This microcirculatory damage can be demonstrated by near-infrared spectroscopy (NIRS). The aim of this study was to compare microvascular reactivity by NIRS during a dynamic vascular occlusion test in healthy smokers and nonsmokers volunteers. Twenty healthy volunteers (10 men, 10 women), aged from 22 to 38years old, were included after approval of the local Ethics Committee and divided into two groups: smokers (n=10) and nonsmokers (n=10). Tissue oxygen saturation (StO2) was measured at the level of each individual's calves during an ischemia and reperfusion test. In addition, during the ischemia phase, the slope of decline in StO2 was determined. Therefore, for each group, we were able to deduce the speed of desaturation (ΔStO2/ischemia time). The same was applied for resaturation rates during the reperfusion phase (ΔStO2/reperfusion time). StO2 values were comparable at all experimental steps between smokers and nonsmokers. During the vascular occlusion test, rates of desaturation were the same between smokers and nonsmokers [respectively 3.7%·min−1 (range 2.5-12.6) and 3.7%·min−1 (range 1.8-15.1); p=0.50]. It was the same for the rate of resaturation [smokers 30.4%·min−1 (range 14.2-51.6) and nonsmokers 30.5%·min−1 (range 18.6-44.5); p=0.82]. NIRS study of microvascular reactivity during a dynamic vascular occlusion test did not reveal any difference between smokers and nonsmokers. Therefore, NIRS could not be sensitive enough to highlight endothelial dysfunction in healthy subjects exposed to tobacco smoke. Springer Science+Business Media New York, 2014 Near-infrared spectroscopy nationallicence Vascular occlusion test nationallicence Microcirculatory nationallicence Tobacco nationallicence Zamparini Guillaume Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Butin Géraldine Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Fischer Marc-Olivier Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Gérard Jean-Louis Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Hanouz Jean-Luc Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Fellahi Jean-Luc Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 555-559 1387-1307 29:5<555 2015 29 10877 https://doi.org/10.1007/s10877-014-9631-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9631-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zamparini Guillaume Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 700 1- Butin Géraldine Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 700 1- Fischer Marc-Olivier Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 700 1- Gérard Jean-Louis Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 700 1- Hanouz Jean-Luc Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 700 1- Fellahi Jean-Luc Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 555-559 1387-1307 29:5<555 2015 29 10877