caa a22 4500 605510423 CHVBK 20210128100645.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10877-014-9632-0 doi (NATIONALLICENCE)springer-10.1007/s10877-014-9632-0 Effect of propofol and remifentanil on a somatosensory evoked potential indicator of pain perception intensity in volunteers [Elektronische Daten] [Ana Castro, Pedro Amorim, Catarina Nunes, Fernando de Almeida] Somatosensory evoked potentials (SEPs) have been linked to noxious activation and stimulus intensity. In this exploratory study we investigated the impact of anaesthetic drugs on SEPs and pain ratings, to assess their applicability as an objective measure of the nociception/anti-nociception balance. Following institutional approval and written informed consent, 10 healthy adult volunteers were enrolled (29.5±9.1years, 63.0±8.9kg and 171.4±7.2). Median nerve electrical stimulation was adjusted according to volunteers' sensitive, motor and painful thresholds (PT). Baseline SEPs were registered, and remifentanil and propofol administered using a stair scheme TCI. For each drug combination a 1.3×PT stimulus was administered, and volunteers evaluated pain intensity in a numerical rating scale (0-10). SEPs' amplitudes and latencies were normalized by the baseline values, reducing volunteers' intervariability. Stimulation currents varied between 6-52mA (1.3×PT) and pain ratings between 0 and 9. Cortical SEPs latencies were decreased for higher stimulus intensities (P<0.01), accompanied by increased pain ratings (P<0.01). An individually adjusted/normalized ratio based on cortical SEPs amplitude and interpeak latency is proposed( $$R_{Norm}$$ R N o r m ): $$R_{Norm}$$ R N o r m and NSR were significantly correlated in three out of nine subjects, and $$R_{Norm}$$ R N o r m and remifentanil Ce were significantly correlated in two (low number of evaluation points). $$R_{Norm}$$ R N o r m was shown to decrease with increasing doses of propofol and remifentanil (P<0.05). The proposed metric was depressed by anaesthetics and reflected pain evaluations. Further research is necessary to increase the number of volunteers and drugs' combination, to assess its applicability during surgically adequate anesthetic leves. Springer Science+Business Media New York, 2014 Pain nationallicence Nociception nationallicence Monitoring nationallicence Somatosensory evoked potentials (SEPs) nationallicence TIVA nationallicence Castro Ana Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, sn, 4200-465, Porto, Portugal aut Amorim Pedro Centro de Investigação Clínica em Anestesiologia, Serviço de Anestesiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal aut Nunes Catarina Centro de Investigação Clínica em Anestesiologia, Serviço de Anestesiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal aut de Almeida Fernando Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, sn, 4200-465, Porto, Portugal aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 561-567 1387-1307 29:5<561 2015 29 10877 https://doi.org/10.1007/s10877-014-9632-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9632-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Castro Ana Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, sn, 4200-465, Porto, Portugal aut NATIONALLICENCE 700 1- Amorim Pedro Centro de Investigação Clínica em Anestesiologia, Serviço de Anestesiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- Nunes Catarina Centro de Investigação Clínica em Anestesiologia, Serviço de Anestesiologia, Hospital de Santo António, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal aut NATIONALLICENCE 700 1- de Almeida Fernando Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, sn, 4200-465, Porto, Portugal aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/5(2015-10-01), 561-567 1387-1307 29:5<561 2015 29 10877