caa a22 4500 605510547 CHVBK 20210128100646.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10877-014-9607-1 doi (NATIONALLICENCE)springer-10.1007/s10877-014-9607-1 Intrathecal drug delivery for chronic pain management-scope, limitations and future [Elektronische Daten] [M. Czernicki, G. Sinovich, I. Mihaylov, B. Nejad, S. Kunnumpurath, G. Kodumudi, N. Vadivelu] Intrathecal drug delivery system (IDDS) is a targeted therapy system for treating pain and muscle spasm. IDDS is recommended for the treatment of chronic pain which does not respond to optimal medical management. The aim of this review article is to give an up to date and concise account of the use of IDDS. It will explore the main indications, pre-implantation trials and different implantation techniques, the licensing of drugs for intrathecal use and the adverse effects and benefits of this therapy. IDDS is an invasive technique, which can result in severe morbidity and mortality. The up to date knowledge gained from this article along with the recommendations for improving safety in patients receiving IDDS, makes it a valuable resource for healthcare practitioners. Continued research, including outcome studies of this therapy continues to be necessary. Springer Science+Business Media New York, 2014 Chronic non-malignant pain nationallicence Cancer pain nationallicence Intrathecal drug delivery system nationallicence Czernicki M. Department of Pain Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK aut Sinovich G. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut Mihaylov I. Department of Pain Medicine, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK aut Nejad B. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut Kunnumpurath S. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut Kodumudi G. School of Liberal Arts and Science, University of Connecticut, Storrs, CT, USA aut Vadivelu N. Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA aut Journal of Clinical Monitoring and Computing Springer Netherlands 29/2(2015-04-01), 241-249 1387-1307 29:2<241 2015 29 10877 https://doi.org/10.1007/s10877-014-9607-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10877-014-9607-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Czernicki M. Department of Pain Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK aut NATIONALLICENCE 700 1- Sinovich G. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut NATIONALLICENCE 700 1- Mihaylov I. Department of Pain Medicine, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK aut NATIONALLICENCE 700 1- Nejad B. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut NATIONALLICENCE 700 1- Kunnumpurath S. Department of Pain Medicine, Epsom and St Helier University Hospitals NHS Trust, Epsom, UK aut NATIONALLICENCE 700 1- Kodumudi G. School of Liberal Arts and Science, University of Connecticut, Storrs, CT, USA aut NATIONALLICENCE 700 1- Vadivelu N. Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA aut NATIONALLICENCE 773 0- Journal of Clinical Monitoring and Computing Springer Netherlands 29/2(2015-04-01), 241-249 1387-1307 29:2<241 2015 29 10877