caa a22 4500 605513392 CHVBK 20210128100700.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00894-015-2663-8 doi (NATIONALLICENCE)springer-10.1007/s00894-015-2663-8 Effects on lipid bilayer and nitrogen distribution induced by lateral pressure [Elektronische Daten] [Yu Wang, Liang Chen, Xiaogang Wang, Chaoqing Dai, Junlang Chen] The lateral pressure exerted on cell membrane is of great importance to signal transduction. Here, we perform molecular dynamics simulation to explore how lateral pressure affects the biophysical properties of lipid bilayer as well as nitrogen distribution in the membrane. Our results show that both physical properties of cell membrane and nitrogen distribution are highly sensitive to the lateral pressure. With the increasing lateral pressure, area per lipid drops and thickness of membrane increases obviously, while nitrogen molecules are more congested in the center of lipid bilayer than those under lower lateral pressure. These results suggest that the mechanism of nitrogen narcosis may be related to the lateral pressure. Graphical Abstract (a) Schematic illustration of pressure exerted on the membrane. Carbon (cyan), oxygen (red), nitrogen (blue) and phosphorous (tan) in head groups are shown by using big spheres, while the lipid tails are shown as dynamicbonds. Nitrogen molecules are depicted as the yellow balls. Water molecules are omitted for clarity. (b) Probability density of the z direction of nitrogen molecules, where the z axis is normal to the lipid bilayer. The center of the lipid bilayer is fixed at z = 0 nm Springer-Verlag Berlin Heidelberg, 2015 Lateral pressure nationallicence Lipid bilayer nationallicence Molecular Dynamics Simulation nationallicence Nitrogen nationallicence Wang Yu School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut Chen Liang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut Wang Xiaogang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut Dai Chaoqing School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut Chen Junlang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut Journal of Molecular Modeling Springer Berlin Heidelberg 21/5(2015-05-01), 1-6 1610-2940 21:5<1 2015 21 894 https://doi.org/10.1007/s00894-015-2663-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00894-015-2663-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Yu School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut NATIONALLICENCE 700 1- Chen Liang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut NATIONALLICENCE 700 1- Wang Xiaogang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut NATIONALLICENCE 700 1- Dai Chaoqing School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut NATIONALLICENCE 700 1- Chen Junlang School of Sciences, Zhejiang A & F University, 311300, Lin'an, China aut NATIONALLICENCE 773 0- Journal of Molecular Modeling Springer Berlin Heidelberg 21/5(2015-05-01), 1-6 1610-2940 21:5<1 2015 21 894