caa a22 4500 605514542 CHVBK 20210128100705.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00360-014-0877-1 doi (NATIONALLICENCE)springer-10.1007/s00360-014-0877-1 The evolution of nitric oxide signalling in vertebrate blood vessels [Elektronische Daten] [John Donald, Leonard Forgan, Melissa Cameron] Nitric oxide is one of the most important signalling molecules involved in the regulation of physiological function. It first came to prominence when it was discovered that the vascular endothelium of mammals synthesises and releases nitric oxide (NO) to mediate a potent vasodilation. Subsequently, it was shown that NO is synthesised in the endothelium by a specific isoform of nitric oxide synthase (NOS) called NOS3. Following this discovery, it was assumed that an endothelial NO/NOS3 system would be present in all vertebrate blood vessels. This review will discuss the latest genomic, anatomical and physiological evidence which demonstrates that an endothelial NO/NOS3 signalling is not ubiquitous in non-mammalian vertebrates, and that there have been key evolutionary steps that have led to the endothelial NO signalling system being a regulatory system found only in reptiles, birds and mammals. Furthermore, the emerging role of nitrite as an endocrine source of NO for vascular regulation is discussed. Springer-Verlag Berlin Heidelberg, 2014 Nitric oxide nationallicence Nitric oxide synthase nationallicence Vertebrate nationallicence Nitrite nationallicence Endothelium nationallicence Vasodilation nationallicence ACh : Acetylcholine nationallicence cGMP : Guanosine 3′:5′-cyclic monophosphate nationallicence EDH : Endothelium-derived hyperpolarisation nationallicence EDRF : Endothelium-derived relaxing factor nationallicence ETC : Electron transport chain nationallicence GC : Guanylyl cyclase nationallicence GTP : Guanosine triphosphate nationallicence Hb : Haemoglobin nationallicence IHC : Immunohistochemistry nationallicence IR : Immunoreactivity nationallicence NADPH : Nicotinamide adenine dinucleotide phosphate nationallicence l -NAME : N 5-[imino(nitroamino)methyl]-l-ornithine methyl ester monohydrochloride nationallicence NO : Nitric oxide nationallicence NOS : Nitric oxide synthase nationallicence ODQ : 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one nationallicence PDZ : Post synaptic density protein (PSD95)/drosophila disc large tumour suppressor protein/zona occludens-1 protein domain nationallicence ROS : Reactive oxygen species nationallicence SIN-1 : 3-Morpholinosyndnomine nationallicence SNP : Sodium nitroprusside nationallicence WGD : Whole genome duplication nationallicence Donald John School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut Forgan Leonard School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut Cameron Melissa School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut Journal of Comparative Physiology B Springer Berlin Heidelberg 185/2(2015-02-01), 153-171 0174-1578 185:2<153 2015 185 360 https://doi.org/10.1007/s00360-014-0877-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00360-014-0877-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Donald John School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Forgan Leonard School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Cameron Melissa School of Life and Environmental Sciences, Deakin University, 3217, Geelong, VIC, Australia aut NATIONALLICENCE 773 0- Journal of Comparative Physiology B Springer Berlin Heidelberg 185/2(2015-02-01), 153-171 0174-1578 185:2<153 2015 185 360