caa a22 4500 605520402 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00223-015-0015-4 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0015-4 The Effects of Re-challenge in Patients with a History of Acute Anterior Uveitis Following Intravenous Zoledronate [Elektronische Daten] [Dipika Patel, Anne Horne, Borislav Mihov, Angela Stewart, Ian Reid, Charles McGhee] To determine the incidence of adverse ocular side effects following re-challenge in patients who previously developed ocular symptoms following intravenous zoledronate. Secondary data analysis of a large, prospective, randomized, double-blind, placebo-controlled clinical trial was performed. Participants consisted of postmenopausal females with osteopenia randomized to placebo (N=1000) or zoledronate 5mg (N=1001) intravenous infusion. Recruitment occurred over a 2-year period, with the first infusion being administered at recruitment, and subsequent infusions every 18months. Eight participants developed acute anterior uveitis (AAU) (diagnosed by an ophthalmologist) following the first infusion of zoledronate. Following appropriate ophthalmic treatment, no patients had visual loss or other ocular sequelae. One further participant reported "sore red eyes” but did not attend for ophthalmology review. Six participants declined further infusions. The remaining three participants were administered two further zoledronate infusions, 18months apart, and none developed any ocular symptoms following each infusion. As a precaution, two of these participants were examined by an ophthalmologist 3days after their second infusion and neither had ocular symptoms or signs of AAU and no subsequent ocular side effects. AAU following zoledronate infusion is likely to be part of the acute phase response. If treated promptly under the care of an ophthalmologist, the visual prognosis is excellent. The results of this study suggest that the development of AAU should not be a contraindication to further infusion. However, in such cases, patients should be warned of the symptoms of AAU (ocular pain, redness, photophobia or blurred vision) and should be promptly referred to an ophthalmologist if symptoms develop. Springer Science+Business Media New York, 2015 Acute anterior uveitis nationallicence Bisphosphonate nationallicence Osteoporosis nationallicence Zoledronate nationallicence Re-challenge nationallicence Patel Dipika Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand aut Horne Anne Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut Mihov Borislav Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut Stewart Angela Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut Reid Ian Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut McGhee Charles Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 58-61 0171-967X 97:1<58 2015 97 223 https://doi.org/10.1007/s00223-015-0015-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0015-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patel Dipika Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand aut NATIONALLICENCE 700 1- Horne Anne Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Mihov Borislav Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Stewart Angela Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- Reid Ian Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand aut NATIONALLICENCE 700 1- McGhee Charles Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 58-61 0171-967X 97:1<58 2015 97 223