Positive Association Between Adipose Tissue and Bone Stiffness
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0008-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0008-3 | ||
| 245 | 0 | 0 | |a Positive Association Between Adipose Tissue and Bone Stiffness |h [Elektronische Daten] |c [R. Berg, H. Wallaschofski, M. Nauck, R. Rettig, M. Markus, R. Laqua, N. Friedrich, A. Hannemann] |
| 520 | 3 | |a Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20-79years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general population. As potential predictors of bone stiffness, VAT and abdominal SAT are not superior to easily available measures like BMI or WC. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Anthropometric measures |2 nationallicence | |
| 690 | 7 | |a Visceral adipose tissue |2 nationallicence | |
| 690 | 7 | |a Subcutaneous adipose tissue |2 nationallicence | |
| 690 | 7 | |a Quantitative ultrasound |2 nationallicence | |
| 700 | 1 | |a Berg |D R. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Wallaschofski |D H. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Nauck |D M. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Rettig |D R. |u Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany |4 aut | |
| 700 | 1 | |a Markus |D M. |u Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Laqua |D R. |u Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Friedrich |D N. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | |
| 700 | 1 | |a Hannemann |D A. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/1(2015-07-01), 40-49 |x 0171-967X |q 97:1<40 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0008-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0008-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Berg |D R. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wallaschofski |D H. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nauck |D M. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rettig |D R. |u Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Markus |D M. |u Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Laqua |D R. |u Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Friedrich |D N. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hannemann |D A. |u Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/1(2015-07-01), 40-49 |x 0171-967X |q 97:1<40 |1 2015 |2 97 |o 223 | ||