caa a22 4500 605520410 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00223-015-0008-3 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0008-3 Positive Association Between Adipose Tissue and Bone Stiffness [Elektronische Daten] [R. Berg, H. Wallaschofski, M. Nauck, R. Rettig, M. Markus, R. Laqua, N. Friedrich, A. Hannemann] Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20-79years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general population. As potential predictors of bone stiffness, VAT and abdominal SAT are not superior to easily available measures like BMI or WC. Springer Science+Business Media New York, 2015 Anthropometric measures nationallicence Visceral adipose tissue nationallicence Subcutaneous adipose tissue nationallicence Quantitative ultrasound nationallicence Berg R. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut Wallaschofski H. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut Nauck M. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut Rettig R. Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany aut Markus M. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany aut Laqua R. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany aut Friedrich N. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut Hannemann A. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 40-49 0171-967X 97:1<40 2015 97 223 https://doi.org/10.1007/s00223-015-0008-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0008-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berg R. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut NATIONALLICENCE 700 1- Wallaschofski H. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut NATIONALLICENCE 700 1- Nauck M. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut NATIONALLICENCE 700 1- Rettig R. Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany aut NATIONALLICENCE 700 1- Markus M. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany aut NATIONALLICENCE 700 1- Laqua R. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany aut NATIONALLICENCE 700 1- Friedrich N. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut NATIONALLICENCE 700 1- Hannemann A. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 40-49 0171-967X 97:1<40 2015 97 223