caa a22 4500 605520437 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00223-015-0005-6 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0005-6 The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats [Elektronische Daten] [Yuki Aikawa, Umon Agata, Yuya Kakutani, Michito Higano, Satoshi Hattori, Hitomi Ogata, Ikuko Ezawa, Naomi Omi] There is a concern that the combination of exercise with food intake reduction has a risk of reducing bone strength and bone mass in young female athletes. We examined the influence of the interaction of voluntary running exercise and food restriction on bone in young female rats. Seven-week-old female Sprague-Dawley rats were divided into four groups: the sedentary and ad libitum feeding group (SED), voluntary running exercise and ad libitum feeding group (EX), sedentary and 30% food restriction group (SED-FR), and voluntary running exercise and 30% food restriction group (EX-FR). The experiment lasted 12weeks. Statistical analysis was carried out by two-way analysis of variance with exercise and restriction as the between-subjects factors. As a result, there were significant interactions of running and restriction on energy availability, breaking force, breaking energy, and bone mineral density (BMD). Breaking force and energy in the EX group were significantly higher than in the SED group; breaking force and energy were significantly lower in the EX-FR group than in the EX group, and breaking force in the EX-FR group was significantly lower than that in the SED-FR group. BMD in the EX-FR group was significantly lower than in the EX and SED-FR groups. These results suggest that food restriction induced low bone strength in young female rats engaging in voluntary running exercise. Also, through the interaction of exercise and food restriction, voluntary running exercise combined food restriction, unlike ad libitum feeding conditions, induced low bone strength, and low BMD in young female rats. Springer Science+Business Media New York, 2015 Running nationallicence Food restriction nationallicence Bone strength nationallicence Young female rat nationallicence Low energy availability nationallicence Aikawa Yuki Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Agata Umon Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Kakutani Yuya Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Higano Michito Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Hattori Satoshi Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Ogata Hitomi Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Ezawa Ikuko Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, 112-8681, Bunkyo-ku, Tokyo, Japan aut Omi Naomi Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 90-99 0171-967X 97:1<90 2015 97 223 https://doi.org/10.1007/s00223-015-0005-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0005-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aikawa Yuki Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Agata Umon Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Kakutani Yuya Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Higano Michito Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Hattori Satoshi Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ogata Hitomi Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ezawa Ikuko Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, 112-8681, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Omi Naomi Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, 305-8572, Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 90-99 0171-967X 97:1<90 2015 97 223