caa a22 4500 605520445 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00223-015-0001-x doi (NATIONALLICENCE)springer-10.1007/s00223-015-0001-x The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis [Elektronische Daten] [Le Wang, Liangbin Gao, Dan Jin, Peng Wang, Bo Yang, Wen Deng, Zhongyu Xie, Yong Tang, Yanfeng Wu, Huiyong Shen] Low bone mineral density (BMD) is an important complication of ankylosing spondylitis (AS) that seriously affects men and their quality of life, even in young patients. However, the relationships among redox; levels of bone turnover markers (BTMs), inflammatory markers and disease activity; and low BMD in AS require clarification. We recruited 102 men aged 30-39year with AS and 102 healthy, sex- and age-matched controls for this cross-sectional study. The subjects were analyzed for lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Significantly lower BMD and corresponding T-scores were observed in the AS patients compared with the controls (P<0.05). The oxidant biomarker and antioxidant levels were significantly (P<0.05) higher and lower, respectively, in the AS subjects compared with the controls, and the bone resorption and inflammatory marker levels were higher (P<0.05). In subgroup analyses, the patients with osteoporosis or active disease had the highest levels of oxidant biomarkers (P<0.05). Furthermore, the BMD T-scores in AS were found to be negatively correlated with oxidative status (P<0.05). Multivariate binary logistic analysis showed that low BMD in the AS patients was associated with higher levels of advanced oxidation protein products, malondialdehyde and C-terminal telopeptide of type I collagen; lower levels of glutathione peroxidase; and higher scores of a bath ankylosing spondylitis metrology index. In conclusion, imbalanced redox was independently associated with low BMD in young men with AS and may play an important role in the pathogenesis of AS-related low BMD. Springer Science+Business Media New York, 2015 Ankylosing Spondylitis (AS) nationallicence Bone mineral density (BMD) nationallicence Bone turnover markers (BTM) nationallicence Oxidant/antioxidant status nationallicence Osteoporosis nationallicence Wang Le Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Gao Liangbin Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Jin Dan Institute of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou, People's Republic of China aut Wang Peng Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Yang Bo Institute of Orthopaedics and Traumatology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China aut Deng Wen Biotherapy Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Xie Zhongyu Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Tang Yong Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Wu Yanfeng Biotherapy Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Shen Huiyong Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 12-22 0171-967X 97:1<12 2015 97 223 https://doi.org/10.1007/s00223-015-0001-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0001-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Le Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Gao Liangbin Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Jin Dan Institute of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Wang Peng Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Yang Bo Institute of Orthopaedics and Traumatology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Deng Wen Biotherapy Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Xie Zhongyu Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Tang Yong Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Wu Yanfeng Biotherapy Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Shen Huiyong Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, 510120, Guangzhou, Guangdong, People's Republic of China aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/1(2015-07-01), 12-22 0171-967X 97:1<12 2015 97 223