Assessment of Fracture Risk in A Population of Postmenopausal Italian Women: A Comparison of Two Different Tools
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0009-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0009-2 | ||
| 245 | 0 | 0 | |a Assessment of Fracture Risk in A Population of Postmenopausal Italian Women: A Comparison of Two Different Tools |h [Elektronische Daten] |c [Gloria Bonaccorsi, Enrica Fila, Carlo Cervellati, Arianna Romani, Melchiore Giganti, Maurizio Rossini, Pantaleo Greco, Leo Massari] |
| 520 | 3 | |a The main objective of this study was to compare in the assessment of risk of fractures in postmenopausal women two algorithms for 10-year fracture risk evaluation, the WHO-endorsed FRAX® and the Italian FRAX-derived version (DeFRA), which considers BMD of different bone sites and allows the inclusion of other data. In a secondary analysis, we compared the performance of the tools in discriminating subjects who sustained previous major fractures from those who did not. The 10-year fracture risk score was evaluated in a sample of 989 climacteric women using FRAX and DeFRA tools. Bone mineral density was also included in the calculation of these algorithms. Comparing how the subjects were assigned to different risk classes by the two tools, we found that DeFRA attributed higher risk categories than FRAX, among women in the subgroups between 50 and 59 and, mostly, 60-69years of age. ROC curve analysis showed that DeFRA had the same discriminative ability to identify previous major osteoporotic fractures compared to FRAX (AUC=0.74 for both). If confirmed by prospective studies, our findings would suggest that DeFRA might be ascribed as at least equivalent to FRAX or perhaps slightly most appropriate in the categorization of the fracture risk, particularly in women aged 60-69years, a period in which bone densitometry analysis is highly recommended. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Menopause |2 nationallicence | |
| 690 | 7 | |a Fracture risk assessment |2 nationallicence | |
| 690 | 7 | |a FRAX |2 nationallicence | |
| 690 | 7 | |a DeFRA |2 nationallicence | |
| 700 | 1 | |a Bonaccorsi |D Gloria |u Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Fila |D Enrica |u Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Cervellati |D Carlo |u Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Romani |D Arianna |u Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Giganti |D Melchiore |u Department of Morphology, Surgery and Experimental Medicine, Laboratory of Nuclear Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Rossini |D Maurizio |u Rheumatology Unit, Department of Medicine, University of Verona, P.le L. Scuro n 2, 37134, Verona, Italy |4 aut | |
| 700 | 1 | |a Greco |D Pantaleo |u Department of Morphology, Surgery and Experimental Medicine, Section of Obstetric and Gynaecology, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | |
| 700 | 1 | |a Massari |D Leo |u Department of Morphology, Surgery and Experimental Medicine, Section of Orthopedic Clinic, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/1(2015-07-01), 50-57 |x 0171-967X |q 97:1<50 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0009-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0009-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bonaccorsi |D Gloria |u Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fila |D Enrica |u Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cervellati |D Carlo |u Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Romani |D Arianna |u Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Giganti |D Melchiore |u Department of Morphology, Surgery and Experimental Medicine, Laboratory of Nuclear Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rossini |D Maurizio |u Rheumatology Unit, Department of Medicine, University of Verona, P.le L. Scuro n 2, 37134, Verona, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Greco |D Pantaleo |u Department of Morphology, Surgery and Experimental Medicine, Section of Obstetric and Gynaecology, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Massari |D Leo |u Department of Morphology, Surgery and Experimental Medicine, Section of Orthopedic Clinic, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/1(2015-07-01), 50-57 |x 0171-967X |q 97:1<50 |1 2015 |2 97 |o 223 | ||