caa a22 4500 605520496 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00223-015-0049-7 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0049-7 The Trochanteric Localization is a Mediator of Slower Short-Term Functional Recovery in Overweight and Obese Elderly Women with Recent Hip Fracture: The BREAK Study [Elektronische Daten] [Stefano Gonnelli, Carla Caffarelli, Stefania Rossi, Paola Siviero, Stefania Maggi, Gaetano Crepaldi, Ranuccio Nuti] Abstracts: The hypothesis tested in this study, carried out on elderly Italian women with recent hip fracture, was to assess the extent to which the effect of a condition of being overweight/obese on short-term functional recovery as evaluated by the "time to permitted load” could be explained by a mediator variable (type of hip fracture). We studied 727 women aged 60years or over with a recent low trauma surgically treated hip fracture and for whom an information on post-surgery complications and on the time to permitted load was available. To assess for mediation, the statistical analyses were carried out following the procedure described by Baron and Kenny. In this study, 46% of women with hip fracture presented a time to permitted load of ≥10days. The women with a post-surgery time to permitted load of ≥10days showed a significantly higher proportion of trochanteric fracture localization (72.1 vs 42%), of total overweight/obesity (46.5 vs 36.8%) and of post-surgery complications (38.8 vs 18.8%). The mediating effect of hip fracture localization on the association between overweight/obesity and the time of permitted load was demonstrated and confirmed in a multivariate logistic regression model. This study, carried out using a "mediator” statistical analysis, suggests that in elderly women with hip fracture being overweight/obese is associated with a slower short-term functional recovery as evaluated by the time to permitted load and that this association is mediated by the trochanteric localization of hip fracture. Springer Science+Business Media New York, 2015 Hip fracture nationallicence Trochanteric fracture nationallicence Mediation analysis nationallicence Overweight nationallicence Obesity nationallicence Permitted load nationallicence Gonnelli Stefano Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut Caffarelli Carla Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut Rossi Stefania Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy aut Siviero Paola CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut Maggi Stefania CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut Crepaldi Gaetano CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut Nuti Ranuccio Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 560-567 0171-967X 97:6<560 2015 97 223 https://doi.org/10.1007/s00223-015-0049-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0049-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gonnelli Stefano Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut NATIONALLICENCE 700 1- Caffarelli Carla Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut NATIONALLICENCE 700 1- Rossi Stefania Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy aut NATIONALLICENCE 700 1- Siviero Paola CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut NATIONALLICENCE 700 1- Maggi Stefania CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut NATIONALLICENCE 700 1- Crepaldi Gaetano CNR Aging Branch, Institute of Neuroscience, Padua, Italy aut NATIONALLICENCE 700 1- Nuti Ranuccio Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 560-567 0171-967X 97:6<560 2015 97 223