caa a22 4500 605520534 CHVBK 20210128100735.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00223-015-0057-7 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0057-7 A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet [Elektronische Daten] [Hyang Ok, Meron Gebreamanuel, Sang Oh, Hyejin Jeon, Won Lee, Oran Kwon] The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague-Dawley rats (8weeks old) were randomized into eight groups: sham-operated rats with low-fat control diet+vehicle, OVX rats with low-fat control diet+vehicle, OVX rats with high-fat diet (HFD)+vehicle, OVX rats with HFD+vehicle+exercise, OVX rats with HFD+PR (400mg/kg body weight/day p.o.), OVX rats with HFD+PR+exercise, OVX rats with HFD+17β-estradiol (0.5mg/kg body weight/day p.o.), OVX rats with HFD+17β-estradiol+exercise. Bone microarchitecture, bone turnover markers (e.g., plasma alkaline phosphatase and osteocalcin), expressions of osteogenic and resorptive gene markers in the bone were measured. Eight weeks of PR and/or aerobic exercise improved cortical microarchitecture of the femur and decreased markers of bone turnover and expression of skeletal osteoclastogenic genes in the femur. PR supplementation combined with exercise preserved bone loss induced by estrogen deficiency and should be investigated further as an alternative to hormone replacement therapy for preventing osteoporosis in postmenopausal women. Springer Science+Business Media New York, 2015 Ovariectomy nationallicence Postmenopausal nationallicence Osteoporosis nationallicence Pueraria lobata nationallicence Rehmannia glutinosa nationallicence Exercise nationallicence Ok Hyang Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Gebreamanuel Meron Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Oh Sang Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Jeon Hyejin Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Lee Won Department of Exercise Science, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Kwon Oran Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 624-633 0171-967X 97:6<624 2015 97 223 https://doi.org/10.1007/s00223-015-0057-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0057-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ok Hyang Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Gebreamanuel Meron Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Oh Sang Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Jeon Hyejin Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lee Won Department of Exercise Science, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kwon Oran Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 624-633 0171-967X 97:6<624 2015 97 223