caa a22 4500 605520550 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00223-015-0046-x doi (NATIONALLICENCE)springer-10.1007/s00223-015-0046-x Negative Impact of Aromatase Inhibitors on Proximal Femoral Bone Mass and Geometry in Postmenopausal Women with Breast Cancer [Elektronische Daten] [Su Lee, Kyoung Kim, J. Brown, Alan Brett, Yun Roh, Dae Kang, Byeong Park, Yumie Rhee] Aromatase inhibitors (AIs), the standard therapy for estrogen receptor- or progesterone receptor-positive breast cancer in postmenopausal women, lead to increased hip fractures in breast cancer patients. To investigate the mechanism of increased incidence of hip fractures in breast cancer patients treated with AIs, we evaluated bone mineral density (BMD) in the cortical and trabecular compartments and assessed femoral geometry using quantitative computed tomography (QCT) in breast cancer patients. In total, 249 early breast cancer patients who underwent QCT in their fifties (mean age 54.3years) were retrospectively analyzed. Proximal femoral BMD and geometrical parameters were compared. In all regions of the proximal femur, cortical areal BMDs were lower in the AI group than in the non-AI group (p<0.05). Cortical thickness of the femoral neck, trochanter, and total hip was significantly lower in the AI group compared with the non-AI group (p<0.05). Analysis of the narrowest section of the femoral neck showed significantly thinner cortical bone and smaller cortical area in the AI group than in the non-AI group (p<0.05), especially in the superoposterior quadrant. Bone strength parameters in the femoral neck, such as the section modulus and cross-sectional moment of inertia, were significantly lower in the AI group than in the non-AI group (p<0.05). In conclusion, AI treatment in breast cancer patients is associated with deterioration of femoral cortical BMD and geometry, which could contribute in site-specific weakened bone strength and increased incidence of hip fractures. Springer Science+Business Media New York, 2015 Aromatase inhibitor nationallicence Breast cancer nationallicence Quantitative computed tomography nationallicence Bone geometry nationallicence Bone strength nationallicence Lee Su Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, Korea aut Kim Kyoung Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut Brown J. Mindways Software Inc., Austin, TX, USA aut Brett Alan Mindways Software Inc., Austin, TX, USA aut Roh Yun Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea aut Kang Dae Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea aut Park Byeong Division of Breast Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea aut Rhee Yumie Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, Korea aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 551-559 0171-967X 97:6<551 2015 97 223 https://doi.org/10.1007/s00223-015-0046-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0046-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Su Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyoung Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea aut NATIONALLICENCE 700 1- Brown J. Mindways Software Inc., Austin, TX, USA aut NATIONALLICENCE 700 1- Brett Alan Mindways Software Inc., Austin, TX, USA aut NATIONALLICENCE 700 1- Roh Yun Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kang Dae Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Park Byeong Division of Breast Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Rhee Yumie Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, Korea aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/6(2015-12-01), 551-559 0171-967X 97:6<551 2015 97 223