caa a22 4500 605520631 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00223-015-0016-3 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0016-3 Do Non-collagenous Proteins Affect Skeletal Mechanical Properties? [Elektronische Daten] [Stacyann Morgan, Atharva Poundarik, Deepak Vashishth] The remarkable mechanical behavior of bone is attributed to its complex nanocomposite structure that, in addition to mineral and collagen, comprises a variety of non-collagenous matrix proteins or NCPs. Traditionally, NCPs have been studied as signaling molecules in biological processes including bone formation, resorption, and turnover. Limited attention has been given to their role in determining the mechanical properties of bone. Recent studies have highlighted that NCPs can indeed be lost or modified with aging, diseases, and drug therapies. Homozygous and heterozygous mice models of key NCP provide a useful approach to determine the impact of NCPs on bone morphology as well as matrix quality, and to carry out detailed mechanical analysis for elucidating the pathway by which NCPs can affect the mechanical properties of bone. In this article, we present a systematic analysis of a large cohort of NCPs on bone's structural and material hierarchy, and identify three principal pathways by which they determine bone's mechanical properties. These pathways include alterations of bone morphological parameters crucial for bone's structural competency, bone quality changes in key matrix parameters (mineral and collagen), and a direct role as load-bearing structural proteins. Springer Science+Business Media New York, 2015 Non-collagenous proteins nationallicence Bone quality nationallicence Bone morphology nationallicence Mineralization nationallicence Mechanical properties nationallicence Fracture nationallicence Morgan Stacyann Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut Poundarik Atharva Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut Vashishth Deepak Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 281-291 0171-967X 97:3<281 2015 97 223 https://doi.org/10.1007/s00223-015-0016-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0016-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morgan Stacyann Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut NATIONALLICENCE 700 1- Poundarik Atharva Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut NATIONALLICENCE 700 1- Vashishth Deepak Center for Biotechnology & Interdisciplinary Studies (Rm 2213) and Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, 12180, Troy, NY, USA aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 281-291 0171-967X 97:3<281 2015 97 223