caa a22 4500 605520666 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00223-015-9984-6 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9984-6 Stock S. Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., 60611-3008, Chicago, IL, USA aut The Mineral-Collagen Interface in Bone [Elektronische Daten] [S. Stock] The interface between collagen and the mineral reinforcement phase, carbonated hydroxyapatite (cAp), is essential for bone's remarkable functionality as a biological composite material. The very small dimensions of the cAp phase and the disparate natures of the reinforcement and matrix are essential to the material's performance but also complicate study of this interface. This article summarizes what is known about the cAp-collagen interface in bone and begins with descriptions of the matrix and reinforcement roles in composites, of the phases bounding the interface, of growth of cAp growing within the collagen matrix, and of the effect of intra- and extrafibrilar mineral on determinations of interfacial properties. Different observed interfacial interactions with cAp (collagen, water, non-collagenous proteins) are reviewed; experimental results on interface interactions during loading are reported as are their influence on macroscopic mechanical properties; conclusions of numerical modeling of interfacial interactions are also presented. The data suggest interfacial interlocking (bending of collagen molecules around cAp nanoplatelets) and water-mediated bonding between collagen and cAp are essential to load transfer. The review concludes with descriptions of areas where new research is needed to improve understanding of how the interface functions. Springer Science+Business Media New York, 2015 Bone nationallicence Mineral-collagen interface nationallicence Apatite nationallicence Collagen nationallicence Non-collagenous proteins nationallicence Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 262-280 0171-967X 97:3<262 2015 97 223 https://doi.org/10.1007/s00223-015-9984-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9984-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stock S. Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., 60611-3008, Chicago, IL, USA aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 262-280 0171-967X 97:3<262 2015 97 223