caa a22 4500 605520682 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00223-015-9996-2 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9996-2 Garnero Patrick INSERM UMR 1033, Lyon, France aut The Role of Collagen Organization on the Properties of Bone [Elektronische Daten] [Patrick Garnero] Bone is a complex tissue constituted by a collagen matrix filled in with crystal of hydroxyapatite (HAP). Bone mechanical properties are influenced by the collagen matrix which is organized into hierarchical structures from the individual type I collagen heterotrimer flanked by linear telopeptides at each end to the collagen fibrils that are interconnected by enzymatic and non-enzymatic cross-links. Although most studies focused on the role of collagen cross-links in bone strength, other organizational features may also play a role. At the molecular level it has been shown that homotrimer of type I collagen found in bone tissue of some patients with osteogenesis imperfecta (OI) is characterized by decreased mechanical competence compared to the regular heterotrimer. The state of C-telopeptide isomerization—which can be estimated by the measurement in body fluids of the native and isomerized isoforms—has also been shown to be associated with bone strength, particularly the post-yield properties independent of bone size and bone mineral density. Other higher hierarchical features of collagen organization have shown to be associated with changes in bone mechanical behavior in ex vivo models and may also be relevant to explain bone fragility in diseases characterized by collagen abnormalities e.g., OI and Paget's disease. These include the orientation of collagen fibrils in a regular longitudinal direction, the D-spacing period between collagen fibrils and the collagen-HAP interfacial bonding. Preliminary data indicate that some of these organizational features can change during treatment with bisphosphonate, raloxifene, and PTH suggesting that they may contribute to their anti-fracture efficacy. It remains however to be determined which of these parameters play a specific and independent role in bone matrix properties, what is the magnitude of mechanical strength explained by collagen organization, whether they are relevant to explain osteoporosis-induced bone fragility, and how they could be monitored non-invasively to develop efficient bone quality biomarkers. Springer Science+Business Media New York, 2015 Bone matrix nationallicence Bone strength nationallicence Collagen organization nationallicence Type I collagen homotrimer nationallicence Osteogenesis imperfecta nationallicence Paget's disease nationallicence Osteoporosis nationallicence Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 229-240 0171-967X 97:3<229 2015 97 223 https://doi.org/10.1007/s00223-015-9996-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9996-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Garnero Patrick INSERM UMR 1033, Lyon, France aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/3(2015-09-01), 229-240 0171-967X 97:3<229 2015 97 223